Childhood trauma, dimensions of psychopathology and the clinical expression of bipolar disorders: A pathway analysis.
Journal of Psychiatric Research. 2017-12-01; 95: 37-45
DOI: 10.1016/j.jpsychires.2017.07.013
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1. J Psychiatr Res. 2017 Dec;95:37-45. doi: 10.1016/j.jpsychires.2017.07.013.
Epub 2017 Jul 29.
Childhood trauma, dimensions of psychopathology and the clinical expression of
bipolar disorders: A pathway analysis.
Etain B(1), Lajnef M(2), Henry C(3), Aubin V(4), Azorin JM(5), Bellivier F(6),
Bougerol T(7), Courtet P(8), Gard S(9), Kahn JP(10), Passerieux C(11), Leboyer
M(12); FACE-BD Clinical Coordinating Center (FondaMental Foundation); FACE-BD
Data Coordinating Center (FondaMental Foundation); FACE-BD Clinical Sites and
Principal Collaborators in France.
Collaborators: Henry C, Etain B, Leboyer M, Laouamri H, Souryis K, Godin O,
Raust A(13), Sportiche S(14), Geoffroy PA(14), Aouizerate B(15), Desage A(15),
Olie E(16), Ducasse D(16), Moliere F(16), Belzeaux R(17), Viglianaise N(17),
Lescalier L(17), Job S(18), Cohen R(18), Wajsbrot-Elgrabli O(18), Polosan M(19),
Garcon S(19), Hardy-Bayle MC(20), Roux P(20), Kayser N(20), Grevin I(20), Loftus
J(21), Albertini L(21).
Author information:
(1)AP-HP, GH Saint-Louis – Lariboisière – Fernand Widal, Pôle Neurosciences,
Paris, France; Université Paris Diderot, UMR-S 1144, Paris, France; Centre for
Affective Disorders, Department of Psychological Medicine, Institute of
Psychiatry, Psychology & Neuroscience, King’s College London, London, UK;
Fondation Fondamental, Créteil, France. Electronic address:
.
(2)Inserm, U955, Equipe Psychiatrie Translationnelle, Créteil, France.
(3)Fondation Fondamental, Créteil, France; Inserm, U955, Equipe Psychiatrie
Translationnelle, Créteil, France; Université Paris Est, Faculté de Médecine,
Créteil, France; AP-HP, Hôpitaux Universitaires Henri Mondor, DHU Pepsy, Pôle de
Psychiatrie et d’Addictologie, Créteil, France; Institut Pasteur, Unité
Perception et Mémoire, Paris, France.
(4)Fondation Fondamental, Créteil, France; Service de Psychiatrie, Centre
Hospitalier Princesse-Grace, Avenue Pasteur, Monaco.
(5)Fondation Fondamental, Créteil, France; Pôle de Psychiatrie, Hôpital Sainte
Marguerite, Assistance Publique Hôpitaux de Marseille, France; Aix-Marseille
Université, CNRS, CRN2M UMR 7286, Marseille, France.
(6)AP-HP, GH Saint-Louis – Lariboisière – Fernand Widal, Pôle Neurosciences,
Paris, France; Université Paris Diderot, UMR-S 1144, Paris, France; Fondation
Fondamental, Créteil, France.
(7)Fondation Fondamental, Créteil, France; Clinique Universitaire de
Psychiatrie, CHU de Grenoble, Grenoble, France.
(8)Fondation Fondamental, Créteil, France; Département d’Urgence et Post Urgence
Psychiatrique, CHRU Montpellier, INSERM U1061, Université Montpellier 1,
Montpellier, France.
(9)Fondation Fondamental, Créteil, France; Centre Expert Trouble Bipolaire, Pôle
de Psychiatrie Générale Universitaire, Centre Hospitalier Charles Perrens,
Bordeaux, France.
(10)Fondation Fondamental, Créteil, France; Université de Lorraine, CHU de Nancy
et Pôle 6 de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de
Nancy, 1 rue du Docteur Archambault, Laxou Cedex, France.
(11)Fondation Fondamental, Créteil, France; Université de Versailles
Saint-Quentin, Centre Hospitalier de Versailles, Service de Psychiatrie Adulte,
Le Chesnay, France.
(12)Fondation Fondamental, Créteil, France; Inserm, U955, Equipe Psychiatrie
Translationnelle, Créteil, France; Université Paris Est, Faculté de Médecine,
Créteil, France; AP-HP, Hôpitaux Universitaires Henri Mondor, DHU Pepsy, Pôle de
Psychiatrie et d’Addictologie, Créteil, France.
(13)Center in Creteil, France.
(14)Center in Paris, France.
(15)Center in Bordeaux, France.
(16)Center in Montpellier, France.
(17)Center in Marseille, France.
(18)Center in Nancy, France.
(19)Center in Grenoble, France.
(20)Center in Versailles, France.
(21)Center in Monaco, France.
BACKGROUND: This study aims at testing for paths from childhood abuse to
clinical indicators of complexity in bipolar disorder (BD), through dimensions
of affective dysregulation, impulsivity and hostility.
METHOD: 485 euthymic patients with BD from the FACE-BD cohort were included from
2009 to 2014. We collect clinical indicators of complexity/severity: age and
polarity at onset, suicide attempt, rapid cycling and substance misuse. Patients
completed questionnaires to assess childhood emotional, sexual and physical
abuses, affective lability, affect intensity, impulsivity, motor and attitudinal
hostility.
RESULTS: The path-analysis demonstrated significant associations between
emotional abuse and all the affective/impulsive dimensions (p