Childhood history of behavioral inhibition and comorbidity status in 256 adults with social phobia.
Journal of Affective Disorders. 2011-03-01; 129(1-3): 338-341
DOI: 10.1016/j.jad.2010.07.031
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1. J Affect Disord. 2011 Mar;129(1-3):338-41. doi: 10.1016/j.jad.2010.07.031.
Epub 2010 Aug 24.
Childhood history of behavioral inhibition and comorbidity status in 256 adults
with social phobia.
Rotge JY(1), Grabot D, Aouizerate B, Pélissolo A, Lépine JP, Tignol J.
Author information:
(1)Department of Psychiatry, Charles Perrens Hospital, Bordeaux, France.
BACKGROUND: Behavioral inhibition (BI), a heritable temperament, predisposes one
to an increased risk of social phobia. Recent investigations have reported that
BI may also be a precursor to anxiety as well as depressive and alcohol-related
disorders, which are frequently comorbid with social phobia. In the present
study, we explored the relationship between BI and psychiatric disorders in 256
adults with a primary diagnosis of social phobia.
METHODS: BI severity was retrospectively assessed with the Retrospective
Self-Report of Inhibition (RSRI). The severity of social phobia and the presence
of comorbid diagnoses were evaluated with the Liebowitz Social Anxiety Scale
(LSAS) and the Mini-International Neuropsychiatric Interview, respectively.
RESULTS: The RSRI score was significantly and positively correlated with both
the LSAS score and the occurrence of a major depressive disorder. No significant
association was found with other anxiety and substance-related disorders.
LIMITATION: The assessment of BI was retrospective and self-reported.
CONCLUSION: A childhood history of BI was associated with an increased risk of
depressive comorbidity in social phobia.
Copyright © 2010 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.jad.2010.07.031
PMID: 20797795 [Indexed for MEDLINE]