Chicoric acid, a new compound able to enhance insulin release and glucose uptake.

Didier Tousch, Anne-Dominique Lajoix, Eric Hosy, Jacqueline Azay-Milhau, Karine Ferrare, Céline Jahannault, Gérard Cros, Pierre Petit
Biochemical and Biophysical Research Communications. 2008-12-01; 377(1): 131-135
DOI: 10.1016/j.bbrc.2008.09.088

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1. Biochem Biophys Res Commun. 2008 Dec 5;377(1):131-5. doi:
10.1016/j.bbrc.2008.09.088. Epub 2008 Oct 1.

Chicoric acid, a new compound able to enhance insulin release and glucose uptake.

Tousch D(1), Lajoix AD, Hosy E, Azay-Milhau J, Ferrare K, Jahannault C, Cros G,
Petit P.

Author information:
(1)Faculté de Pharmacie, Centre de Pharmacologie & Innovation dans le Diabète,
CNRS UMR 5232, Université Montpellier 1, Montpellier cedex 5, France.

Caffeic acid and chlorogenic acid (CGA), a mono-caffeoyl ester, have been
described as potential antidiabetic agents. Using in vitro studies, we report the
effects of a dicaffeoyl ester, chicoric acid (CRA) purified from Cichorium
intybus, on glucose uptake and insulin secretion. Our results show that CRA and
CGA increased glucose uptake in L6 muscular cells, an effect only observed in the
presence of stimulating concentrations of insulin. Moreover, we found that both
CRA and CGA were able to stimulate insulin secretion from the INS-1E
insulin-secreting cell line and rat islets of Langerhans. In the later case, the
effect of CRA is only observed in the presence of subnormal glucose levels. Patch
clamps studies show that the mechanism of CRA and CGA was different from that of
sulfonylureas, as they did not close K(ATP) channels. Chicoric acid is a new
potential antidiabetic agent carrying both insulin sensitizing and
insulin-secreting properties.

DOI: 10.1016/j.bbrc.2008.09.088
PMID: 18834859 [Indexed for MEDLINE]

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