Chemogenetic stimulation of adult neurogenesis, and not neonatal neurogenesis, is sufficient to improve long-term memory accuracy
Progress in Neurobiology. 2022-12-01; 219: 102364
DOI: 10.1016/j.pneurobio.2022.102364
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Lods M(1), Mortessagne P(1), Pacary E(1), Terral G(2), Farrugia F(1), Mazier W(3), Masachs N(1), Charrier V(1), Cota D(3), Ferreira G(4), Abrous DN(5), Tronel S(6).
Author information:
(1)Univ. Bordeaux, INSERM, Magendie, U1215, Neurogenesis and Pathophysiology Group, F-3300 Bordeaux, France.
(2)Univ. Bordeaux, INSERM, Magendie, U1215, Endocannabinoids and Neuroadaptation Group, F-3300 Bordeaux, France.
(3)Univ. Bordeaux, INSERM, Magendie, U1215, Energy Balance and Obesity Group, F-3300 Bordeaux, France.
(4)Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeurO, UMR 1286, Nutrition and Integrative Neurobiology Group, F-3300 Bordeaux, France.
(5)Univ. Bordeaux, INSERM, Magendie, U1215, Neurogenesis and Pathophysiology Group, F-3300 Bordeaux, France. Electronic address: .
(6)Univ. Bordeaux, INSERM, Magendie, U1215, Neurogenesis and Pathophysiology Group, F-3300 Bordeaux, France. Electronic address: .
Hippocampal adult neurogenesis is involved in many memory processes from learning, to remembering and forgetting. However, whether or not the stimulation of adult neurogenesis is a sufficient condition to improve memory performance
remains unclear. Here, we developed and validated, using ex-vivo
electrophysiology, a chemogenetic approach that combines selective tagging and
activation of discrete adult-born neuron populations. Then we demonstrated that,
in rats, this activation can improve accuracy and strength of remote memory.
These results show that stimulation of adult-born neuron activity can counteract
the natural fading of memory traces that occurs with the passage of time. This
opens up new avenues for treating memory problems that may arise over time.
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.pneurobio.2022.102364
PMID: 36244613
Conflict of interest statement: Competing interests The authors declare no
competing interests.