Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2006-12-01; 75(6): 413-418
DOI: 10.1016/j.plefa.2006.08.002
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1. Prostaglandins Leukot Essent Fatty Acids. 2006 Dec;75(6):413-8. doi:
10.1016/j.plefa.2006.08.002. Epub 2006 Oct 2.
Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of
patients with diabetic retinopathy and age-related macular degeneration.
Matias I(1), Wang JW, Moriello AS, Nieves A, Woodward DF, Di Marzo V.
Author information:
(1)Endocannabinoid Research Group, Institute of Biomolecular Chemistry,
Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072 Arco Felice, Pozzuoli
(Napoli), Italy.
Cannabinoid receptors and the endocannabinoids (anandamide
(N-arachidonoylethanolamine–AEA) and 2-arachidonoylglycerol (2-AG)), as well as
the AEA congener, palmitoylethanolamide (PEA), are involved in ocular
physiology. We measured endocannabinoid and PEA levels by isotope-dilution
liquid chromatography-mass spectrometric analysis in post-mortem eye tissues of
patients with diabetic retinopathy (DR) or age-related macular degeneration
(AMD). In eyes with DR, significantly enhanced levels of AEA were found in the
retina ( approximately 1.8-fold), ciliary body ( approximately 1.5-fold) and, to
a lesser extent, cornea ( approximately 1.3-fold). Surprisingly, 2-AG levels
were significantly higher ( approximately 3-fold) only in the iris, whereas PEA
levels only slightly increased ( approximately 1.3-fold) in the ciliary body. In
eyes with AMD, significantly enhanced levels of AEA were found in the choroid (
approximately 1.3-fold), ciliary body ( approximately 1.4-fold) and cornea (
approximately 1.4-fold), whereas in the retina only a trend towards an increase
( approximately 1.5-fold) was observed. The tissue- and disease-selective nature
of the changes observed suggests that the compounds analyzed here may play
different roles in the control of eye function under different pathological
conditions.
DOI: 10.1016/j.plefa.2006.08.002
PMID: 17011761 [Indexed for MEDLINE]