Cerebrospinal Fluid Levels of Kininogen-1 Indicate Early Cognitive Impairment in Parkinson’s Disease
Mov Disord. 2020-08-15; 35(11): 2101-2106
DOI: 10.1002/mds.28192
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Markaki I(1), Bergström S(2), Tsitsi P(1), Remnestål J(2), Månberg A(2), Hertz E(1), Paslawski W(1), Sorjonen K(1), Uhlén M(3)(4), Mangone G(5), Carvalho S(5), Rascol O(6), Meissner WG(7)(8), Magnin E(9), Wüllner U(10), Corvol JC(5), Nilsson P(2), Svenningsson P(1).
Author information:
(1)Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
(2)Division of Affinity Proteomics, Department of Protein Science, KTH-Royal
Institute of Technology, SciLifeLab, Stockholm, Sweden.
(3)Division of Systems Biology, Department of Protein Science, KTH-Royal
Institute of Technology, SciLifeLab, Stockholm, Sweden.
(4)Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
(5)Sorbonne Université, Assistance Publique Hôpitaux de Paris, NS-PARK/FCRIN
network, Institut du Cerveau et de la Moelle épinière, ICM, Inserm U 1127, CNRS
UMR 7225, Department of Neurology, Hôpital Pitié-Salpêtrière, Paris, France.
(6)Centre d’Investigation Clinique CIC1436, Centre Expert Parkinson de Toulouse,
Département Neurosciences et pharmacologie Clinique, NS-PARK/FCRIN network,
NeuroToul COEN Center; INSERM, University Hospital of Toulouse and University of
Toulouse 3, Toulouse, France.
(7)Service de Neurologie, Centre Expert Parkinson, NS-PARK/FCRIN network, CHU
Bordeaux, Bordeaux, France and Université de Bordeaux, Institut des Maladies
Neurodégénératives, UMR 5293, CNRS, Bordeaux, France.
(8)Department of Medicine, University of Otago, Christchurch, and New Zealand
Brain Research Institute, Christchurch, New Zealand.
(9)Regional Parkinson Expert Center and Regional Memory Center (CMRR), Department
of Neurology, CHU Besançon, Besançon, France.
(10)University Hospital Bonn and German Centre for Neurodegenerative Diseases
(DZNE), Bonn, Germany.
BACKGROUND: Cognitive impairment is common in patients with PD. Core markers of
Alzheimer’s dementia have been related also to PD dementia, but no
disease-specific signature to predict PD dementia exists to date.
OBJECTIVES: The aim of this study was to investigate CSF markers associated with
cognition in early PD.
METHODS: A high-throughput suspension bead array examined 216 proteins in CSF of
74 PD patients in the AETIONOMY project. Cognitive function was assessed with
Repeatable Battery for the Assessment of the Neuropsychological Status, Montreal
Cognitive Assessment, and Mini-Mental State Examination.
RESULTS: Of 69 patients with complete data, 34 had high (≥90) and 35 had low
Repeatable Battery for the Assessment of the Neuropsychological Status total
score (