Cerebral Blood Flow by Using Pulsed Arterial Spin-Labeling in Elderly Subjects with White Matter Hyperintensities

A.J. Bastos-Leite, J.P.A. Kuijer, S.A.R.B. Rombouts, E. Sanz-Arigita, E.C. van Straaten, A.A. Gouw, W.M. van der Flier, P. Scheltens, F. Barkhof
AJNR Am J Neuroradiol. 2008-05-01; 29(7): 1296-1301
DOI: 10.3174/ajnr.a1091

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1. AJNR Am J Neuroradiol. 2008 Aug;29(7):1296-301. doi: 10.3174/ajnr.A1091. Epub
2008 May 1.

Cerebral blood flow by using pulsed arterial spin-labeling in elderly subjects
with white matter hyperintensities.

Bastos-Leite AJ(1), Kuijer JP, Rombouts SA, Sanz-Arigita E, van Straaten EC, Gouw
AA, van der Flier WM, Scheltens P, Barkhof F.

Author information:
(1)Image Analysis Center, VU University Medical Center, Amsterdam, the

BACKGROUND AND PURPOSE: On MR imaging, white matter hyperintensities (WMH) on
T2-weighted images are generally considered as a surrogate marker of ischemic
small vessel disease in elderly subjects. Pulsed arterial spin-labeling (PASL) is
a noninvasive MR perfusion-weighted technique. We hypothesized that elderly
subjects with diffuse confluent WMH should have lower cerebral blood flow (CBF)
measurements than subjects with punctiform or beginning confluent WMH.
MATERIALS AND METHODS: MR images of 21 subjects (13 women; mean age, 76 years;
SD, 5), stratified for the degree of WMH, from a single center within the
multinational Leukoaraiosis and Disability (LADIS) study, were investigated. CBF
images were obtained by means of quantitative imaging of perfusion by using a
single-subtraction second version, with thin-section TI periodic saturation PASL.
Values of cortical gray matter, subcortical (including white matter and deep gray
matter), and global CBF were calculated. CBF measurements of subjects with
diffuse confluent WMH (n = 7) were compared with those of subjects with
punctiform or beginning confluent WMH (n = 14).
RESULTS: Subjects with diffuse confluent WMH were found to have approximately 20%
lower mean global CBF (43.5 mL/100 mL/min; SD, 6.3) than subjects with punctiform
or beginning confluent WMH (57.9 mL/100 mL/min; SD, 8.6; P < .01), as well as approximately 20% lower mean subcortical (P < .01) and cortical gray matter CBF (P < .05). CONCLUSION: PASL revealed a significant reduction of CBF measurements in elderly subjects with diffuse confluent WMH. DOI: 10.3174/ajnr.A1091 PMCID: PMC8119130 PMID: 18451090 [Indexed for MEDLINE]

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