Brief interventions for improving adherence in schizophrenia: A pilot study using electronic medication event monitoring
Psychiatry Research. 2020-03-01; 285: 112780
DOI: 10.1016/j.psychres.2020.112780
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Tessier A(1), Dupuy M(2), Baylé FJ(3), Herse C(4), Lange AC(5), Vrijens B(6),
Schweitzer P(7), Swendsen J(7), Misdrahi D(8).
Author information:
(1)Centre Hospitalier Charles Perrens, Pole de Psychiatrie 347, 121 rue de la
Bechade, Bordeaux 33076, France; CNRS-UMR 5287, Université de Bordeaux, Institut
de Neurosciences Cognitives et Intégratives d’Aquitaine (INCIA), 146 rue Léo
Saignat, Bordeaux 33076, France.
(2)CNRS-UMR 5287, Université de Bordeaux, Institut de Neurosciences Cognitives
et Intégratives d’Aquitaine (INCIA), 146 rue Léo Saignat, Bordeaux 33076,
France; EA 4136-Handicap et Système Nerveux, Université de Bordeaux, 146 rue Léo
Saignat, Bordeaux 33076, France.
(3)Hôpital Sainte-Anne, Université Paris V-Descartes, 1 Rue Cabanis, Paris
75014, France.
(4)Centre Hospitalier Charles Perrens, Pole de Psychiatrie 347, 121 rue de la
Bechade, Bordeaux 33076, France.
(5)Department of Public Health, University of Liège, Place du 20 Août 7, Liège
4000, Belgium.
(6)Department of Public Health, University of Liège, Place du 20 Août 7, Liège
4000, Belgium; AARDEX Group, 24, Rue des Cyclistes Frontière 4600 Visé, Belgium.
(7)CNRS-UMR 5287, Université de Bordeaux, Institut de Neurosciences Cognitives
et Intégratives d’Aquitaine (INCIA), 146 rue Léo Saignat, Bordeaux 33076,
France; EPHE, PSL Research University, Les Patios Saint-Jacques, 4-14 Rue
Ferrus, Paris 75014, France.
(8)Centre Hospitalier Charles Perrens, Pole de Psychiatrie 347, 121 rue de la
Bechade, Bordeaux 33076, France; CNRS-UMR 5287, Université de Bordeaux, Institut
de Neurosciences Cognitives et Intégratives d’Aquitaine (INCIA), 146 rue Léo
Saignat, Bordeaux 33076, France. Electronic address:
.
Poor medication adherence remains frequent in schizophrenia. The present study
examined the efficacy of two month-long pilot interventions using the Medication
Event Monitoring System (MEMS®). Thirty-three outpatients at high risk for
relapse were randomized to receive a smartphone-based intervention, a
nurse-based intervention, or treatment as usual. All patients then used the
MEMS® to objectively measure medication adherence over six months. No
differences were observed in adherence measures or relapse rates across the
three groups. When using electronic medication monitoring as an objective
measure of adherence, easily-implemented interventions may not significantly
improve adherence in patients at high risk for relapse.
Copyright © 2020 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.psychres.2020.112780
PMID: 31954541 [Indexed for MEDLINE]