Brain dissection photogrammetry: a tool for studying human white matter connections integrating ex-vivo and in-vivo multimodal datasets
Nat Commun. 2025-11-06; 16(1):
DOI: 10.1038/s41467-025-64788-y
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https://www.bordeaux-neurocampus.fr/12644
1. Nat Commun. 2025 Nov 6;16(1):9801. doi: 10.1038/s41467-025-64788-y.
Brain dissection photogrammetry: a tool for studying human white matter
connections integrating ex vivo and in vivo multimodal datasets.
Vavassori L(1)(2), Rheault F(3)(4), Nocerino E(5), Annicchiarico L(6), Corsini
F(6), Zigiotto L(6)(7), De Benedictis A(8), Barbareschi M(9), Rozzanigo U(10),
Avesani P(#)(11), Sarubbo S(#)(6)(12), Petit L(#)(4)(13).
Author information:
(1)Department of Neurosurgery, Azienda Provinciale per i Servizi Sanitari
(APSS), « S. Chiara » University-Hospital, Trento, Italy.
.
(2)Department of Cellular, Computational and Integrative Biology (CIBIO), Center
for Medical Sciences (CISMed), Center for Mind and Brain Sciences (CIMeC),
University of Trento, Trento, Italy. .
(3)Sherbrooke Connectivity Imaging Laboratory (SCIL), Université de Sherbrooke,
Sherbrooke, Québec, Canada.
(4)IRP OpTeam, CNRS Biologie, France – Université de Sherbrooke, Sherbrooke,
Canada.
(5)Department of Humanities and Social Sciences, University of Sassari, Sassari,
Italy.
(6)Department of Neurosurgery, Azienda Provinciale per i Servizi Sanitari
(APSS), « S. Chiara » University-Hospital, Trento, Italy.
(7)Department of Psychology, Azienda Provinciale per i Servizi Sanitari (APSS),
« S. Chiara » University-Hospital, Trento, Italy.
(8)Neurosurgery Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy.
(9)Department of Pathological, Histological and Cytological Anatomy, Azienda
Provinciale per i Servizi Sanitari (APSS), « S. Chiara » University-Hospital,
Trento, Italy.
(10)Department of Radiology, Azienda Provinciale per i Servizi Sanitari (APSS),
« S. Chiara » University-Hospital, Trento, Italy.
(11)Neuroinformatics Laboratory (NiLab), Bruno Kessler Foundation (FBK), Trento,
Italy.
(12)Department of Cellular, Computational and Integrative Biology (CIBIO),
Center for Medical Sciences (CISMed), Center for Mind and Brain Sciences
(CIMeC), University of Trento, Trento, Italy.
(13)Université Bordeaux, CNRS, CEA, IMN, GIN, UMR 5293, F-33000, Bordeaux,
France.
(#)Contributed equally
Understanding the architecture of the white matter of the human brain is central
to neuroscience and clinics. Despite major advances in tractography and white
matter dissection, integrating these complementary techniques remains a
longstanding challenge. Here, we introduce BraDiPho (Brain Dissection
Photogrammetry), an open-access resource of high-resolution, fully textured 3D
digital models of layer-by-layer white matter microdissection. The models are
registered to their radiological space, allowing direct alignment of dissection
and neuroimaging data. BraDiPho includes eight hemispheres, enriched with sample
tractography bundles, anatomical annotations, and cortical atlases, establishing
a unified framework for multimodal analyses. Four case studies demonstrate how
BraDiPho supports anatomically grounded investigations, moving beyond classical
side-by-side comparisons toward accurate integration of ex vivo dissection and
in vivo tractography. All data, tools, and scripts are openly available,
enabling customized research and educational applications. BraDiPho offers a
framework to support multimodal investigations of human brain connectivity in
both research and educational contexts.
© 2025. The Author(s).
DOI: 10.1038/s41467-025-64788-y
PMCID: PMC12592512
PMID: 41198692 [Indexed for MEDLINE]
Conflict of interest statement: Competing interests: The authors declare no
competing interests.