Bradykinin parallels thyrotropin-releasing hormone actions on prolactin release from rat anterior pituitary cells.
Neuroendocrinology. 1987-01-01; 46(4): 360-364
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1. Neuroendocrinology. 1987 Oct;46(4):360-4.
Bradykinin parallels thyrotropin-releasing hormone actions on prolactin release
from rat anterior pituitary cells.
Drouhault R(1), Abrous N, David JP, Dufy B.
(1)Laboratoire de Physiologie Elémentaire et Intégrée, CNRS UA 1200, Université
de Bordeaux II, France.
Bradykinin (BK), a nonapeptide, originally discovered in blood, is also present
in neurons and fibers of the hypothalamus. We tested the putative releasing
factor properties of BK on prolactin (PRL) release from anterior pituitary cells
in vitro. BK stimulated the release of PRL in a dose-dependent manner, the
threshold concentration being in the range. 0.1-1.0 nM. The release of PRL
induced by BK at 1 nM concentration was about 2-fold, delayed and sustained over
many minutes. Higher concentrations of BK stimulated PRL release in two phases.
The shape of the BK-induced PRL release was superficially similar to that induced
by thyrotropin-releasing hormone (TRH). 10 nM BK and 10 nM TRH induced about a
4-fold increase in PRL release within 5 min, followed by a gradual recovery to
basal secretion. These results indicate that this peptide can act directly at the
anterior pituitary gland to release PRL. Phorbol ester also promoted PRL release
over the range of 1-10 nM, but the time course of the release was somewhat
PMID: 3118231 [Indexed for MEDLINE]