Birth origin differentially affects depressive-like behaviours: are captive-born cynomolgus monkeys more vulnerable to depression than their wild-born counterparts?
PLoS ONE. 2013-07-04; 8(7): e67711
DOI: 10.1371/journal.pone.0067711
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1. PLoS One. 2013 Jul 4;8(7):e67711. doi: 10.1371/journal.pone.0067711. Print 2013.
Birth origin differentially affects depressive-like behaviours: are captive-born
cynomolgus monkeys more vulnerable to depression than their wild-born
counterparts?
Camus SM(1), Rochais C, Blois-Heulin C, Li Q, Hausberger M, Bezard E.
Author information:
(1)Université Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293,
Bordeaux, France.
BACKGROUND: Adverse early-life experience might lead to the expression of
abnormal behaviours in animals and the predisposition to psychiatric disorder
(e.g. major depressive disorder) in Humans. Common breeding processes employ
weaning and housing conditions different from what happens in the wild.
METHODS: The present study, therefore, investigated whether birth origin impacts
the possible existence of spontaneous atypical/abnormal behaviours displayed by
40 captive-born and 40 wild-born socially-housed cynomolgus macaques in farming
conditions using an unbiased ethological scan-sampling analysis followed by
multifactorial correspondence and hierarchical clustering analyses.
RESULTS: We identified 10 distinct profiles (groups A to J) that significantly
differed on several behaviours, body postures, body orientations, distances
between individuals and locations in the cage. Data suggest that 4 captive-born
and 1 wild-born animals (groups G and J) present depressive-like symptoms,
unnatural early life events thereby increasing the risk of developing
pathological symptoms. General differences were also highlighted between the
captive- and wild-born populations, implying the expression of differential
coping mechanisms in response to the same captive environment.
CONCLUSIONS: Birth origin thus impacts the development of atypical
ethologically-defined behavioural profiles, reminiscent of certain
depressive-like symptoms. The use of unbiased behavioural observations might
allow the identification of animal models of human mental/behavioural disorders
and their most appropriate control groups.
DOI: 10.1371/journal.pone.0067711
PMCID: PMC3701588
PMID: 23861787 [Indexed for MEDLINE]