Binge-like eating in mice.
Int. J. Eat. Disord.. 2009-07-01; 42(5): 402-408
DOI: 10.1002/eat.20637
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1. Int J Eat Disord. 2009 Jul;42(5):402-8. doi: 10.1002/eat.20637.
Binge-like eating in mice.
Consoli D(1), Contarino A, Tabarin A, Drago F.
Author information:
(1)Department of Experimental and Clinical Pharmacology, Medical School,
University of Catania, Catania, Italy.
OBJECTIVE: Given the lack of reliable murine model of binge-like eating, we tried
to induce this pathological behavior in mice.
METHOD: We used an experimental protocol mimicking the etiological factors
involved in the development of binge eating in humans, that is, food restriction,
refeeding (R-R) in presence of high palatable food, and stress (S).
RESULTS: Mice subjected to at least three cycles of R-R plus S (forced swimming
stress), showed a binge-like behavior evident as early as 4 h, persisting 24 h
after stress application and not associated to depressive-like behavior. However,
after the third R-R/S cycle, food intakes of mice returned to normal levels.
DISCUSSION: (i) at least three cycles of R-R plus S are required to promote
abnormal eating in mice, (ii) this is not associated to depressive-like
behaviors, and (iii) the enhanced pathological behavior showed a transient nature
not persisting after the third R-R/S cycle.
DOI: 10.1002/eat.20637
PMID: 19130488 [Indexed for MEDLINE]