Bidirectional control of quantal size by synaptic activity in the hippocampus
Science. 1996-03-01; 271(5253): 1294-1297
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1. Science. 1996 Mar 1;271(5253):1294-7.
Bidirectional control of quantal size by synaptic activity in the hippocampus.
Oliet SH(1), Malenka RC, Nicoll RA.
(1)Department of Cellular and Molecular Pharmacology, University of California,
San Francisco 94143-0450, USA.
Analysis of strontium-induced asynchronous release of quanta from stimulated
synapses revealed that long-term potentiation and long-term depression in the CA1
region of the mammalian hippocampus are associated with an increase and a
decrease, respectively, in quantal size. At a single set of synapses, the
increase in quantal size seen with long-term potentiation was completely reversed
by depotentiating stimuli. Long-term potentiation and depression are also
associated with an increase and decrease, respectively, in the frequency of
quantal events, consistent with an all-or-none regulation (up or down) of
clusters of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors, a change in the release of transmitter, or both.
PMID: 8638114 [Indexed for MEDLINE]