Bidirectional control of quantal size by synaptic activity in the hippocampus

S. H. R. Oliet, R. C. Malenka, R. A. Nicoll
Science. 1996-03-01; 271(5253): 1294-1297
DOI: 10.1126/science.271.5253.1294

Lire sur PubMed

1. Science. 1996 Mar 1;271(5253):1294-7.

Bidirectional control of quantal size by synaptic activity in the hippocampus.

Oliet SH(1), Malenka RC, Nicoll RA.

Author information:
(1)Department of Cellular and Molecular Pharmacology, University of California,
San Francisco 94143-0450, USA.

Analysis of strontium-induced asynchronous release of quanta from stimulated
synapses revealed that long-term potentiation and long-term depression in the CA1
region of the mammalian hippocampus are associated with an increase and a
decrease, respectively, in quantal size. At a single set of synapses, the
increase in quantal size seen with long-term potentiation was completely reversed
by depotentiating stimuli. Long-term potentiation and depression are also
associated with an increase and decrease, respectively, in the frequency of
quantal events, consistent with an all-or-none regulation (up or down) of
clusters of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors, a change in the release of transmitter, or both.

DOI: 10.1126/science.271.5253.1294
PMID: 8638114 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus