Beyond cortical localization in clinico-anatomical correlation
Cortex. 2012-11-01; 48(10): 1262-1287
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1. Cortex. 2012 Nov-Dec;48(10):1262-87. doi: 10.1016/j.cortex.2012.07.001. Epub 2012
Beyond cortical localization in clinico-anatomical correlation.
Catani M(1), Dell’acqua F, Bizzi A, Forkel SJ, Williams SC, Simmons A, Murphy DG,
Thiebaut de Schotten M.
(1)Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute
of Psychiatry, King’s College London, UK.
Last year was the 150th anniversary of Paul Broca’s landmark case report on
speech disorder that paved the way for subsequent studies of cortical
localization of higher cognitive functions. However, many complex functions rely
on the activity of distributed networks rather than single cortical areas. Hence,
it is important to understand how brain regions are linked within large-scale
networks and to map lesions onto connecting white matter tracts. To facilitate
this network approach we provide a synopsis of classical neurological syndromes
associated with frontal, parietal, occipital, temporal and limbic lesions. A
review of tractography studies in a variety of neuropsychiatric disorders is also
included. The synopsis is accompanied by a new atlas of the human white matter
connections based on diffusion tensor tractography freely downloadable on
http://www.natbrainlab.com. Clinicians can use the maps to accurately identify
the tract affected by lesions visible on conventional CT or MRI. The atlas will
also assist researchers to interpret their group analysis results. We hope that
the synopsis and the atlas by allowing a precise localization of white matter
lesions and associated symptoms will facilitate future work on the functional
correlates of human neural networks as derived from the study of clinical
populations. Our goal is to stimulate clinicians to develop a critical approach
to clinico-anatomical correlative studies and broaden their view of clinical
anatomy beyond the cortical surface in order to encompass the dysfunction related
to connecting pathways.
Copyright © 2012 Elsevier Srl. All rights reserved.
PMID: 22995574 [Indexed for MEDLINE]