Basal Ganglia circuits underlying the pathophysiology of levodopa-induced dyskinesia.
Front. Neuroanat.. 2010-01-01; 4:
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1. Front Neuroanat. 2010 Sep 14;4. pii: 131. doi: 10.3389/fnana.2010.00131.
Basal Ganglia circuits underlying the pathophysiology of levodopa-induced
Barroso-Chinea P(1), Bezard E.
(1)Centre National de la Recherche Scientifique UMR 5227, Bordeaux Institute of
Neuroscience, Université Victor-Segalen Bordeaux 2 Bordeaux, France.
Involuntary movements or dyskinesia, represent a debilitating complication of
levodopa therapy for Parkinson’s disease. Dyskinesia is, ultimately, experienced
by the vast majority of the patients. Despite the importance of this problem,
little was known about the cause of dyskinesia, a situation that has dramatically
evolved in the last few years with a focus upon the molecular and signaling
changes induced by chronic levodopa treatment. Departing from this, we here
review the progress made in functional anatomy and neuroimaging that have had a
tremendous impact on our understanding of the anatomo-functional organization of
the basal ganglia in Parkinsonism and dyskinetic states, notably the
demonstration that dyskinesia are linked to a pathological processing of limbic
and cognitive information.