Bacterial lipopolysaccharide-induced systemic inflammation alters perfusion of white matter-rich regions without altering flow in brain-irrigating arteries: Relationship to blood-brain barrier breakdown?

Ibtihel Dhaya, Marion Griton, Gérard Raffard, Mohamed Amri, Bassem Hiba, Jan Pieter Konsman
Journal of Neuroimmunology. 2018-01-01; 314: 67-80
DOI: 10.1016/j.jneuroim.2017.11.009

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1. J Neuroimmunol. 2018 Jan 15;314:67-80. doi: 10.1016/j.jneuroim.2017.11.009. Epub
2017 Nov 20.

Bacterial lipopolysaccharide-induced systemic inflammation alters perfusion of
white matter-rich regions without altering flow in brain-irrigating arteries:
Relationship to blood-brain barrier breakdown?

Dhaya I(1), Griton M(2), Raffard G(3), Amri M(4), Hiba B(3), Konsman JP(5).

Author information:
(1)CNRS, Résonance Magnétique des Systèmes Biologiques, UMR 5536, Bordeaux,
France; Univ. Bordeaux, RMSB, UMR 5536, Bordeaux, France; Laboratoire de
Neurophysiologie Fonctionnelle et Pathologies, UR/11ES09, Faculté des Sciences
Mathématiques, Physiques et Naturelles, Université de Tunis El Manar, Tunis,
Tunisia.
(2)CNRS, Résonance Magnétique des Systèmes Biologiques, UMR 5536, Bordeaux,
France; Univ. Bordeaux, RMSB, UMR 5536, Bordeaux, France; Service de Réanimation
Anesthésie Neurochirurgicale, Centre Hospitalier Universitaire (CHU) de Bordeaux,
Bordeaux, France.
(3)CNRS, Résonance Magnétique des Systèmes Biologiques, UMR 5536, Bordeaux,
France; Univ. Bordeaux, RMSB, UMR 5536, Bordeaux, France.
(4)Laboratoire de Neurophysiologie Fonctionnelle et Pathologies, UR/11ES09,
Faculté des Sciences Mathématiques, Physiques et Naturelles, Université de Tunis
El Manar, Tunis, Tunisia.
(5)CNRS, Résonance Magnétique des Systèmes Biologiques, UMR 5536, Bordeaux,
France; Univ. Bordeaux, RMSB, UMR 5536, Bordeaux, France. Electronic address:
.

To better understand brain dysfunction during sepsis, cerebral arterial blood
flow was assessed with Phase Contrast Magnetic Resonance Imaging, perfusion with
Arterial Spin Labeling and structure with diffusion-weighted Magnetic Resonance
Imaging in rats after intraperitoneal administration of bacterial
lipopolysaccharides. Although cerebral arterial flow was not altered, perfusion
of the corpus callosum region and diffusion parallel to its fibers were higher
after lipopolysaccharide administration as compared to saline injection. In
parallel, lipopolysaccharide induced perivascular immunoglobulin-immunoreactivity
in white matter. These findings indicate that systemic inflammation can result in
increased perfusion, blood-brain barrier breakdown and altered water diffusion in
white matter.

Copyright © 2017 Elsevier B.V. All rights reserved.

DOI: 10.1016/j.jneuroim.2017.11.009
PMID: 29174195

Auteurs Bordeaux Neurocampus