Axonal sensory motor neuropathy in copper-deficient wilson’s disease
Muscle Nerve. 2009-08-01; 40(2): 294-296
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1. Muscle Nerve. 2009 Aug;40(2):294-6. doi: 10.1002/mus.21425.
Axonal sensory motor neuropathy in copper-deficient Wilson’s disease.
Foubert-Samier A(1), Kazadi A, Rouanet M, Vital A, Lagueny A, Tison F, Meissner
(1)Department of Neurology, University Hospital Bordeaux, Haut-Lévêque, Avenue
Magellan, 33604 Pessac Cedex, France.
Copper deficiency may cause myeloneuropathy or progressive limb weakness. By
contrast, Wilson’s disease (WD) is characterized by progressive copper
accumulation with hepatic and neurological impairment and requires life-long
treatment with zinc and/or chelator agents. We report a WD patient who developed
axonal sensory motor neuropathy in the context of copper deficiency due to his
treatment with zinc and chelators. Exhaustive testing for other etiologies was
negative. After treatment adjustment, only mild clinical improvement was noted
during long-term follow-up. Muscle Nerve 40: 294-296, 2009.
PMID: 19609919 [Indexed for MEDLINE]