Atrial fibrillation is a major cause of stroke in apneic patients: a prospective study.
Sleep Medicine. 2017-02-01; 30: 251-254
DOI: 10.1016/j.sleep.2015.07.031
Lire sur PubMed
1. Sleep Med. 2017 Feb;30:251-254. doi: 10.1016/j.sleep.2015.07.031. Epub 2016 Mar
4.
Atrial fibrillation is a major cause of stroke in apneic patients: a prospective
study.
Poli M(1), Philip P(2), Taillard J(3), Debruxelles S(4), Renou P(4), Orgogozo
JM(1), Rouanet F(4), Sibon I(5).
Author information:
(1)CHU Bordeaux, Unité Neurovasculaire, Place Amélie Raba-Léon, 33000 Bordeaux,
France; Université Bordeaux 2, Bordeaux, France.
(2)Université Bordeaux 2, Bordeaux, France; Université Bordeaux, Sommeil,
Attention et Neuropsychiatrie, USR 3413, F-33000 Bordeaux, France; CNRS, SANPSY,
USR 3413, F-33000 Bordeaux, France.
(3)Université Bordeaux, Sommeil, Attention et Neuropsychiatrie, USR 3413, F-33000
Bordeaux, France; CNRS, SANPSY, USR 3413, F-33000 Bordeaux, France.
(4)CHU Bordeaux, Unité Neurovasculaire, Place Amélie Raba-Léon, 33000 Bordeaux,
France.
(5)CHU Bordeaux, Unité Neurovasculaire, Place Amélie Raba-Léon, 33000 Bordeaux,
France; Université Bordeaux 2, Bordeaux, France; INCIA, Bordeaux, France.
Electronic address: .
OBJECTIVES: Large prospective studies have established that sleep-disordered
breathing (SDB) is associated with an increased incidence of cardiovascular and
cerebrovascular diseases. Heterogeneous results have been published about SDB and
ischaemic stroke mechanism. The aim of this study was to evaluate the
relationship between poststroke apneic syndrome and stroke aetiologies according
to the ASCO classification.
METHODS: A total of 134 patients with acute ischaemic cerebrovascular events were
prospectively included. Patients with severe or infratentorial infarctions were
excluded. Stroke risk factors and clinical characteristics were recorded in all
patients. An overnight polygraphy was recorded (Embletta PDS). Apneic patients
were defined if the polygraphy reported an apnea-hypopnea index ≥15. A
standardized diagnosis workup, including serum biological investigation,
evaluation of extra and intracranial arteries and heart morphology and function,
was performed. Stroke mechanism was defined using ASCO and TOAST classifications.
RESULTS: A proportion of 42% (56 of 134) of the patients were diagnosed as having
sleep apneas. Apneic patients were older (p