Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations.
Journal of Neuroscience. 2015-11-18; 35(46): 15339-15352
DOI: 10.1523/jneurosci.0861-15.2015
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1. J Neurosci. 2015 Nov 18;35(46):15339-52. doi: 10.1523/JNEUROSCI.0861-15.2015.
Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations.
Roux L(1), Madar A(1), Lacroix MM(2), Yi C(1), Benchenane K(2), Giaume C(3).
Author information:
(1)Center for Interdisciplinary Research in Biology, Collège de France/Centre
National de la Recherche Scientifique, Unité Mixte de Recherche 7241, Institut
National de la Santé et de la Recherche Médicale U1050, 75231 Paris Cedex 05,
France, University Pierre et Marie Curie, 75005 Paris, France, MemoLife
Laboratory of Excellence and Paris Science Lettre Research University, 75005
Paris, France.
(2)Memory Oscillations and Brain States Team, Laboratory of Neurobiology, Brain
Plasticity Unit, Unité Mixte de Recherche 8249, CNRS, Ecole Supérieure de
Physique et de Chimie Industrielles de la Ville de Paris – ParisTech, 75005
Paris, France.
(3)Center for Interdisciplinary Research in Biology, Collège de France/Centre
National de la Recherche Scientifique, Unité Mixte de Recherche 7241, Institut
National de la Santé et de la Recherche Médicale U1050, 75231 Paris Cedex 05,
France, University Pierre et Marie Curie, 75005 Paris, France, MemoLife
Laboratory of Excellence and Paris Science Lettre Research University, 75005
Paris, France, .
An emergent concept in neurosciences consists in considering brain functions as
the product of dynamic interactions between neurons and glial cells, particularly
astrocytes. Although the role played by astrocytes in synaptic transmission and
plasticity is now largely documented, their contribution to neuronal network
activity is only beginning to be appreciated. In mouse olfactory bulb slices, we
observed that the membrane potential of mitral cells oscillates between UP and
DOWN states at a low frequency (