Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?
Front. Aging Neurosci.. 2014-09-24; 6:
DOI: 10.3389/fnagi.2014.00258
Lire sur PubMed
1. Front Aging Neurosci. 2014 Sep 24;6:258. doi: 10.3389/fnagi.2014.00258.
eCollection 2014.
Astrocytosis in parkinsonism: considering tripartite striatal synapses in
physiopathology?
Charron G(1), Doudnikoff E(1), Canron MH(1), Li Q(2), Véga C(3), Marais S(4),
Baufreton J(1), Vital A(1), Oliet SH(5), Bezard E(6).
Author information:
(1)Institut des Maladies Neurodégénératives, Université de Bordeaux, UMR 5293
Bordeaux, France ; CNRS, Institut des Maladies Neurodégénératives, UMR 5293
Bordeaux, France.
(2)Institute of Laboratory Animal Sciences, Chinese Academy of Medical Science
and Peking Union Medical College Beijing, China.
(3)CNRS, Institut des Maladies Neurodégénératives, UMR 5293 Bordeaux, France ;
UFR Sciences de la Vie, University Pierre et Marie Curie (UPMC) Paris, France.
(4)Bordeaux Imaging Center, UMS 3420, Université de Bordeaux Bordeaux, France ;
CNRS, Bordeaux Imaging Center, UMS 3420 Bordeaux, France ; INSERM, Bordeaux
Imaging Center, US 004 Bordeaux, France.
(5)Neurocentre Magendie, U862, Institut National de la Santé et de la Recherche
Médicale Bordeaux, France.
(6)Institut des Maladies Neurodégénératives, Université de Bordeaux, UMR 5293
Bordeaux, France ; CNRS, Institut des Maladies Neurodégénératives, UMR 5293
Bordeaux, France ; Institute of Laboratory Animal Sciences, Chinese Academy of
Medical Science and Peking Union Medical College Beijing, China.
The current concept of basal ganglia organization and function in physiological
and pathophysiological conditions excludes the most numerous cells in the brain,
i.e., the astrocytes, present with a ratio of 10:1 neuron. Their role in
neurodegenerative condition such as Parkinson’s disease (PD) remains to be
elucidated. Before embarking into physiological investigations of the
yet-to-be-identified « tripartite » synapses in the basal ganglia in general and
the striatum in particular, we therefore characterized anatomically the
PD-related modifications in astrocytic morphology, the changes in astrocytic
network connections and the consequences on the spatial relationship between
astrocytic processes and asymmetric synapses in normal and PD-like conditions in
experimental and human PD. Our results unravel a dramatic regulation of striatal
astrocytosis supporting the hypothesis of a key role in (dys) regulating
corticostriatal transmission. Astrocytes and their various properties might thus
represent a therapeutic target in PD.
DOI: 10.3389/fnagi.2014.00258
PMCID: PMC4174038
PMID: 25309435