Associations of glucocorticoid receptor and corticosteroid-binding globulin gene polymorphisms on fat mass and fat mass distribution in prepubertal obese children.
J Physiol Biochem. 2012-05-12; 68(4): 645-650
DOI: 10.1007/s13105-012-0176-9
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Barat P(1), Corcuff JB, Tauber M, Moisan MP.
Author information:
(1)Université Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286 Bordeaux,
France.
Previous studies conducted in adult obese patients have shown that glucocorticoid
receptor and corticosteroid-binding globulin gene polymorphisms influence
cortisol-driven obesity and metabolic parameters. We investigated the impact of
these polymorphisms in prepubertal obese children that were thoroughly examined
for hypothalamic-pituitary-adrenal axis activity and for metabolic and obesity
parameters. Obese children carrier of the allele G of the BclI polymorphism
within glucocorticoid receptor gene tend to present a higher percentage of fat
mass as well as a decreased cortisol suppression after low-dose dexamethasone as
found in adult studies. Additionally, these allele G carriers show a strong
correlation between truncal fat mass distribution and cortisol response to a
standardized lunch, whereas this correlation is weak in allele C carriers. No
differences were found for obesity or metabolic parameters between genotypes at
the corticosteroid-binding globulin locus. However, allele 90 carriers present
increased 24-h free urinary cortisol. Overall, this study provides new data
showing the influence of glucocorticoid receptor and corticosteroid-binding
globulin genes in obesity and/or cortisol action in prepubertal obese children.
DOI: 10.1007/s13105-012-0176-9
PMID: 22576823 [Indexed for MEDLINE]