Association of a MIND Diet with Brain Structure and Dementia in a French Population.
J Prev Alz Dis. 2022-01-01; :
DOI: 10.14283/jpad.2022.67
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Thomas A(1), Lefèvre-Arbogast S, Féart C, Foubert-Samier A, Helmer C, Catheline G, Samieri C.
Author information:
(1)Aline Thomas, Inserm U1219, Isped, Univ. Bordeaux, CS 61292, 146 rue
Léo-Saignat, F-33076 Bordeaux cedex, France; Phone: + (33) 05 57 57 12 99 Fax: +
(33) 05 57 57 14 86; e-mail: .
BACKGROUND: Adherence to the Mediterranean-DASH Intervention for
Neurodegenerative Delay (MIND) diet, which combines higher consumption of
vegetables, berries, nuts, whole grains, olive oil, fish, beans and poultry,
with lower consumption of meat, sugars and saturated fats, is a promising
strategy to prevent dementia. However, evidence in populations with non-US food
culture, especially from Europe, is limited.
OBJECTIVES: To evaluate the association of a French-adapted MIND diet score with
gray matter volumes, white matter microstructure and incident dementia.
DESIGN AND SETTING: This longitudinal study included participants from the
population-based Three-City Bordeaux cohort (≥65 years), with a follow-up from
June 2001 to February 2018.
PARTICIPANTS: Dementia-free participants at dietary assessment, in 2001-2002,
who underwent systematic detection of incident dementia (over up to 7 visits). A
subset of the cohort was included in an ancillary MRI study in 2010-2011.
MEASUREMENTS: A French-adapted MIND diet score (range, 0-15) was computed from a
148-item Food Frequency Questionnaire and a 24-hour recall administered at home.
Incident dementia and its subtypes were adjudicated by an expert committee; and
gray matter volumes and white matter microstructure were assessed by 3D-T1 MRI
and diffusion-MRI.
RESULTS: Among 1,412 participants (mean age, 75.8 [SD, 4.8]; 63% women),
followed for a median of 9.7 years (maximum 16.3 years), 356 (25.2%) developed
incident dementia. In multivariable-adjusted Cox model, a higher French MIND
diet score was associated with lower risks of dementia and AD (hazard ratios for
1-point of score = 0.89 [95% confidence interval, 0.83-0.95] and 0.88
[0.81-0.96], respectively). In Tract-Based Spatial Statistics analysis of 175
participants included in the MRI sub-study, a higher MIND diet score was
associated with lower diffusivity values in the splenium of the corpus callosum
(P < .05 after Family-Wise Error-correction). In contrast, there was no
significant association of the adapted MIND diet score with gray matter volumes
in Voxel-Based Morphometry analysis.
CONCLUSION: In this cohort of French older adults, higher adherence to the
French MIND diet was associated with a lower dementia risk and with preserved
white matter microstructure. These results provide further evidence for a role
of the MIND diet in the prevention of dementia.
DOI: 10.14283/jpad.2022.67
PMID: 36281669 [Indexed for MEDLINE]
Conflict of interest statement: A. Thomas, S. Lefèvre-Arbogast, A.
Foubert-Samier, C. Helmer, G. Catheline and C. Samieri report no conflict of
interest. C. Féart received fees for conferences from Laboratoire Lescuyer and
Synadiet.