Associating Disrupted Intrinsic Functional Networks with Cognitive and Socio-Affective Skills Following Cerebellar Stroke
Cerebellum. 2024-12-04; 24(1):
DOI: 10.1007/s12311-024-01757-z
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1. Cerebellum. 2024 Dec 4;24(1):1. doi: 10.1007/s12311-024-01757-z.
Associating Disrupted Intrinsic Functional Networks with Cognitive and
Socio-Affective Skills Following Cerebellar Stroke.
Duttagupta S(1), Chanraud S(1)(2), Sebag L(1), Mayo W(1), Catheline G(1)(2),
Poli M(3), Liegey JS(3), Sibon I(4)(5), Berthoz-Landron S(1)(6).
Author information:
(1)University of Bordeaux, INCIA CNRS UMR 5287, Bordeaux, France.
(2)EPHE PSL Research University, Life and Earth Sciences, Paris, France.
(3)CHU Bordeaux, Unité Neurovasculaire, Bordeaux, France.
(4)University of Bordeaux, INCIA CNRS UMR 5287, Bordeaux, France.
.
(5)CHU Bordeaux, Unité Neurovasculaire, Bordeaux, France.
.
(6)Department of Psychiatry for Adolescents and Young Adults, Institut
Mutualiste Montsouris, Paris, France.
Stroke patients often experience post-stroke emotional impairments, yet the
underlying pathophysiology remains unclear. At the brain level, dysregulation of
socio-affective skills should be considered through alterations in brain
networks instead of isolated regions. Investigating network alterations may be
crucial in explaining emotional or cognitive deficits. In this context, and in
line with the dysmetria of thought theory, cerebello-cortical networks’
alterations could explain socio-affective functioning. To examine whether
impairments in intrinsic functional networks following a cerebellar stroke are
associated with poor cognitive and socio-affective performance. Thirty-six
cerebellar stroke patients underwent resting-state functional MRI scans at the
early stage (T1). They were assessed through a battery of clinical evaluations
for cognitive and socio-affective skills. At the chronic stage (T2), evaluations
were repeated with additional ecological momentary assessments (EMA) for
emotional behavior. The global efficiencies of four resting-state functional
brain networks associated with the cerebellum were determined. Patients were
classified into subgroups of high and low functioning based on the evaluations
and compared. Poorer global efficiency in the default-mode network was present
in the subgroup with higher depression (T1: p = 0.034, T2: p = 0.006) and low
EMA positive mood (p = 0.048), while lower efficiency in the dorsal attentional
network was shown in the subgroup with lower verbal memory (T1: p = 0.004, T2:
p = 0.048). Disruptions in intrinsic functional networks are linked to poorer
cognition and emotion for some cerebellar stroke patients, partially supporting
the theory of ‘dysmetria of thought’.
© 2024. The Author(s), under exclusive licence to Springer Science+Business
Media, LLC, part of Springer Nature.
DOI: 10.1007/s12311-024-01757-z
PMID: 39630367 [Indexed for MEDLINE]
Conflict of interest statement: Declarations. Compliance with Ethical Standards:
The authors have no conflicts of interest to disclose. Study procedures included
research involving Human Participants that were approved by the Research Ethics
Committee of Sud-Ouest and Outre-Mer. Informed consent of the participants were
taken based on the principles of the Declaration of Helsinki on Good Clinical
Practice. Competing Interests: The authors declare no competing interests.