Assessment of quality of life with the multiple system atrophy health-related quality of life scale

Wassilios G. Meissner, Alexandra Foubert-Samier, Sandrine Dupouy, Angélique Gerdelat-Mas, Rachel Debs, Fabienne Marquant, Valérie Cochen De Cock, Olivier Rascol, François Tison, Anne Pavy-Le Traon
Mov. Disord.. 2012-10-01; 27(12): 1574-1577
DOI: 10.1002/mds.25174

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1. Mov Disord. 2012 Oct;27(12):1574-7. doi: 10.1002/mds.25174. Epub 2012 Oct 2.

Assessment of quality of life with the multiple system atrophy health-related
quality of life scale.

Meissner WG(1), Foubert-Samier A, Dupouy S, Gerdelat-Mas A, Debs R, Marquant F,
De Cock VC, Rascol O, Tison F, Pavy-Le Traon A.

Author information:
(1)Centre de Référence Atrophie Multisystématisée, CHU de Bordeaux, Pessac,
France.

BACKGROUND: Multiple system atrophy (MSA) has considerable effect on
health-related quality of life (Hr-QoL). The aim of this study was to
prospectively evaluate Hr-QoL by using the MSA health-related Quality of Life
(MSA-QoL) scale.
METHODS: Evaluation of 100 patients at baseline and after a mean follow-up of
11.5 months was performed. Assessment was made of potential associations with
established markers of disease progression. Calculation was performed of
sample-size estimates for various effect sizes.
RESULTS: MSA-QoL scale scores were less responsive to change than Unified MSA
Rating Scale (UMSARS) scores. Responsiveness was largely improved and reasonable
sample-size estimates were obtained when limiting the analysis to items with
significant change over time.
CONCLUSIONS: The UMSARS remains the « gold standard » for
disease-modifying/neuroprotection trials. An MSA-QoL Change Scale, based on the
most responsive items, may become a valuable tool.

Copyright © 2012 Movement Disorder Society.

DOI: 10.1002/mds.25174
PMID: 23033055 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus