Arterial stiffness predicts severe progression in systemic sclerosis: The ERAMS study
Journal of Hypertension. 2007-09-01; 25(9): 1900-1906
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1. J Hypertens. 2007 Sep;25(9):1900-6.
Arterial stiffness predicts severe progression in systemic sclerosis: the ERAMS
Constans J(1), Germain C, Gosse P, Taillard J, Tiev K, Delevaux I, Mouthon L,
Schmidt C, Granel F, Soria P, Lifermann F, Etienne G, Bonnet F, Zoulim K,
Farge-Bancel D, Marie I, Allanore Y, Cabane J, Amonchot A, Macquin-Mavier I,
Saves M, Zannad F, Conri C; ERAMS investigators.
(1)Vascular and Internal Medicine Unit, CHU Bordeaux, Paris, France.
OBJECTIVE: The ERAMS study addressed the value of arterial stiffness in
predicting the severity of systemic sclerosis.
METHODS: ERAMS was a prospective multicentre cohort study including patients with
definite systemic sclerosis. Arterial stiffness was measured by the standardized
non-invasive QKd 100-60 method. Clinical evaluation, biological measurements,
functional respiratory tests and cardiac Doppler echography were performed at
inclusion then each year until 3 years’ follow-up was completed. Progression was
defined as mild (articulations, muscle, oesophagus or skin involvement) or severe
(lung, heart or kidney involvement) by a critical event committee. The prediction
of severe progression was studied for QKd 100-60 as well as clinical and
biological data at baseline by univariate and multivariate analysis.
RESULTS: Ninety-nine patients were included (81 women, 18 men, mean age 57 years,
standard deviation 12.5). Although their blood pressure profile was normal, half
the patients had increased arterial stiffness (QKd 100-60