Aquaporin 4 correlates with apparent diffusion coefficient and hydrocephalus severity in the rat brain: a combined MRI-histological study.
NeuroImage. 2009-08-01; 47(2): 659-666
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1. Neuroimage. 2009 Aug 15;47(2):659-66. doi: 10.1016/j.neuroimage.2009.04.070. Epub
2009 May 3.
Aquaporin 4 correlates with apparent diffusion coefficient and hydrocephalus
severity in the rat brain: a combined MRI-histological study.
Tourdias T(1), Dragonu I, Fushimi Y, Deloire MS, Boiziau C, Brochet B, Moonen C,
Petry KG, Dousset V.
(1)Université Victor Segalen Bordeaux 2, Laboratoire de Neurobiologie des
affections de la myéline, EA2966, France.
Hydrocephalus features include ventricular dilatation and periventricular edema
due to transependymal resorption of cerebrospinal fluid (CSF). Aquaporin 4
(AQP4), a water channel protein located at the blood-brain barrier, might
facilitate the removal of this excess of water from the parenchyma into the
blood. First, we hypothesized a link between AQP4 expression and the severity of
hydrocephalus. We further hypothesized that movements of water through AQP4 could
affect apparent diffusion coefficient (ADC) measurements. Communicating
inflammatory hydrocephalus was induced in 45 rats, and at various stages,
magnetic resonance imaging (MRI) was used to measure CSF volume and
periventricular ADC, with immunostaining being used to determine periventricular
AQP4. We found an up-regulation of periventricular AQP4 in hydrocephalic rats
that was strongly correlated with both CSF volume (Pearson=0.87, p