Approaches to optical neuromodulation from rodents to non-human primates by integrated optoelectronic devices.
2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2011-08-01; :
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1. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:7525-8. doi:
Approaches to optical neuromodulation from rodents to non-human primates by
integrated optoelectronic devices.
Wang J(1), Ozden I, Diagne M, Wagner F, Borton D, Brush B, Agha N, Burwell R,
Sheinberg D, Diester I, Deisseroth K, Nurmikko A.
(1)Department of Physics, School of Engineering.
Methods on rendering neurons in the central nervous system to be light responsive
has led to a boom in using optical neuromodulation as a new approach for
controlling brain states and understanding neural circuits. In addition to the
developing versatility to “optogenetically” labeling of neural cells and their
subtypes by microbiological methods, parallel efforts are under way to design and
implement optoelectronic devices to achieve simultaneous optical neuromodulation
and electrophysiological recording with high spatial and temporal resolution.
Such new device-based technologies need to be developed for full exploitation of
the promise of optogenetics. In this paper we present single- and multi-element
optoelectronic devices developed in our laboratories. The single-unit element,
namely the coaxial optrode, was utilized to characterize the neural responses in
optogenetically modified rodent and primate models. Furthermore, the
multi-element device, integrating the optrode with a 6×6 microelectrode array,
was used to characterize the spatiotemporal spread of neural activity in response
to single-site optical stimulation in freely moving rats. We suggest that the
particular approaches we employed can lead to the emergence of methods where
spatio-temporal optical modulation is integrated with real-time read out from
PMID: 22256079 [Indexed for MEDLINE]