Apolipoprotein e genotype is related to progression of white matter lesion load
Stroke. 2009-07-30; 40(10): 3186-3190
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1. Stroke. 2009 Oct;40(10):3186-90. doi: 10.1161/STROKEAHA.109.555839. Epub 2009 Jul
Apolipoprotein E genotype is related to progression of white matter lesion load.
Godin O(1), Tzourio C, Maillard P, Alpérovitch A, Mazoyer B, Dufouil C.
(1)Inserm Unit 708 Neuroepidemiology, Hôpital la Salpétrière, Paris, France.
BACKGROUND AND PURPOSE: The relationship between white matter lesions (WMLs) and
the apolipoprotein E genotype has been controversial from cross-sectional studies
and no longitudinal finding has been reported. We investigated whether the
apolipoprotein E genotype influences baseline and evolution over 4-year follow-up
of WML volumes in a population-based sample of 1779 nondemented subjects aged 65
to 80 years old at enrollment.
METHODS: The sample consisted of 3C-Dijon study participants who had 2 cerebral
MRIs, at entry and at 4-year follow-up. WML volumes were estimated using a fully
automatic procedure. We performed analysis of covariance to evaluate the
relationship between apolipoprotein E genotype and WML load and progression.
RESULTS: Multivariable analyses showed that epsilon4epsilon4 individuals had both
significantly higher WML volume at baseline and higher WML increase over 4-year
follow-up than noncarriers and heterozygous of the epsilon4 allele for
apolipoprotein E genotype.
CONCLUSION: These findings suggest it might be important to take into account WML
severity when assessing the relationship between apolipoprotein E and dementia.
PMID: 19644067 [Indexed for MEDLINE]