Anti-inflammatories for depression: challenges and ASPIRations.

Courtney Worrell, Bernhard T Baune, Francesco Benedetti, Annamaria Cattaneo, Livia De Picker, Jennifer C Felger, Stefan M Gold, Femke Lamers, Marion Leboyer, Giulia Lombardo, Fanni-Laura Mäntylä, Andrew H Miller, Valeria Mondelli, Brenda W J H Penninx, Luca Sforzini, Dan J Stein, Benedetta Vai, Erik Van der Eycken, Anthony Woods, Carmine M Pariante, Bruno Aouizerate, Bernhard T. Baune, Veronica Begni, Michael Berk, Igor Branchi, Beatrice Bravi, Nadia Cattane, Tommaso Cazzella, Federico Cevoli, Cassey Chambers, Violette Coppens, Christopher Davey, Floriana De Cillis, Olivia Dean, Claudia Delli Colli, Linda El-Ahmad, Jennifer C. Felger, Éimear M. Foley, Pierrette Fortuna, Sarah Fromme, Stefan M. Gold, Luisa Grünberg, Kate Hamilton, Ebrahim Haroon, Neil Harrison, Ben Harrison, Julian Hellmann-Regen, Isabella Heuser, Nadia Hoffman, Krystle Kemp, Golam M. Khandaker, Anastasia Kontogianni, Melisa Kose, Toni Lange, Nicole Mariani, Yuri Milaneschi, Andrew H. Miller, Camilla Monopoli, Manuel Morrens, Naghmeh Nikkheslat, Nigel Olisa, Christian Otte, Carmine M. Pariante, Brenda W.J.H. Penninx, Caitlin Pentland, Sara Poletti, Camila Ribeiro Perez, Maria Simon, Claudio Singh Solorzano, Dan J. Stein, Victoria Stiglbauer, Michael T. Treadway, Chiara Verga, Céline Wessa, Deniz Yildirim Dogan, Zuzanna Zajkowska, Joël Zwiep
The Lancet Psychiatry. 2025-10-01; :
DOI: 10.1016/s2215-0366(25)00308-6

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https://www.bordeaux-neurocampus.fr/12228

Worrell C(1), Baune BT(2), Benedetti F(3), Cattaneo A(4), De Picker L(5), Felger JC(6), Gold SM(7), Lamers F(8), Leboyer M(9), Lombardo G(1), Mäntylä FL(10),
Miller AH(6), Mondelli V(11), Penninx BWJH(8), Sforzini L(11), Stein DJ(12), Vai B(3), Van der Eycken E(10), Woods A(1), Pariante CM(13); ASPIRE Study Consortium.

Collaborators: Aouizerate B, Baune BT, Begni V, Benedetti F, Berk M, Branchi I,
Bravi B, Cattane N, Cattaneo A, Cazzella T, Cevoli F, Chambers C, Coppens V,
Davey C, De Cillis F, De Picker L, Dean O, Delli Colli C, El-Ahmad L, Felger JC,
Foley ÉM, Fortuna P, Fromme S, Gold SM, Grünberg L, Hamilton K, Haroon E,
Harrison N, Harrison B, Hellmann-Regen J, Heuser I, Hoffman N, Kemp K, Khandaker
GM, Kontogianni A, Kose M, Lamers F, Lange T, Leboyer M, Lombardo G, Mäntylä FL,
Mariani N, Milaneschi Y, Miller AH, Mondelli V, Monopoli C, Morrens M,
Nikkheslat N, Olisa N, Otte C, Pariante CM, Penninx BWJH, Pentland C, Poletti S,
Ribeiro Perez C, Sforzini L, Simon M, Singh Solorzano C, Stein DJ, Stiglbauer V,
Treadway MT, Vai B, Van der Eycken E, Verga C, Wessa C, Woods A, Worrell C,
Yildirim Dogan D, Zajkowska Z, Zwiep J.

Author information:
(1)Department of Psychological Medicine, Institute of Psychiatry, Psychology &
Neuroscience, King’s College London, London SE5 9RT, UK.
(2)Department of Psychiatry, University of Münster, Münster, Germany.
(3)Division of Neuroscience, Psychiatry & Clinical Psychobiology Unit, IRCCS
Ospedale San Raffaele, Milan, Italy; University Vita-Salute San Raffaele, Milan,
Italy.
(4)Biological Psychiatric Unit, IRCCS Istituto Centro San Giovanni di Dio
Fatebenefratelli, Brescia, Italy; Department of Pharmacological and Biomolecular
Sciences, University of Milan, Milan, Italy.
(5)University Psychiatric Hospital Campus Duffel, Duffel, Belgium; Collaborative
Antwerp Psychiatric Research Institute, Faculty of Health Sciences, University
of Antwerp, Antwerp, Belgium.
(6)Department of Psychiatry and Behavioural Sciences, Emory University School of
Medicine, Atlanta, GA, USA.
(7)Department of Psychiatry, Campus Benjamin Franklin,
Charité-Universitätsmedizin Berlin, Berlin, Germany.
(8)Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam,
Netherlands; Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, Netherlands.
(9)FondaMental Foundation, Créteil, France; Department of Addictology and
Psychiatry, Université Paris-Est Créteil, AP-HP, Translational Neuropsychiatry
laboratory, Inserm U955, PEPR PROPSY, Créteil, France.
(10)Global Alliance of Mental Illness Advocacy Networks-Europe, Brussels,
Belgium.
(11)Department of Psychological Medicine, Institute of Psychiatry, Psychology &
Neuroscience, King’s College London, London SE5 9RT, UK; National Institute for
Health and Care Research Maudsley Biomedical Research Centre at South London and
Maudsley NHS Foundation Trust and King’s College London, London, UK.
(12)SAMRC Unit on Risk and Resilience in Mental Disorders, Department of
Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South
Africa.
(13)Department of Psychological Medicine, Institute of Psychiatry, Psychology &
Neuroscience, King’s College London, London SE5 9RT, UK; National Institute for
Health and Care Research Maudsley Biomedical Research Centre at South London and
Maudsley NHS Foundation Trust and King’s College London, London, UK. Electronic
address: .

DOI: 10.1016/S2215-0366(25)00308-6
PMID: 41115445

Conflict of interest statement: The following authors report consultancy or
speaker fees: LDP (Boehringer Ingelheim Belgium); SMG (Hexal, Tegus, Angelini,
and Streamed up); FL (Noema Pharma, Novo Nordisk, and Johnson & Johnson); JCF
(Ventus Therapeutics); BVJHP (Neurotorium and Boehringer Ingelheim); BTB
(AstraZeneca, Lundbeck, Pfizer, Takeda, Servier, Bristol Myers Squibb, Otsuka,
LivaNova, Biogen, Angelini, and Janssen–Cilag); AHM (Cerevel Therapeutics,
Freedom Biosciences, and Sirtsei Pharmaceuticals); DJS (Discovery Vitality,
Johnson & Johnson, Kanna, L’Oréal Lundbeck, Orion, Sanofi, Servier, Takeda, and
Vistagen); and CMP (Värde Partners, Compass Pathways, and UCB). All other
authors declare no competing interests. This work was supported by the Wellcome
Trust Advanced Stratification of People with Depression (ASPIRE) Study
(30312/Z/23/Z).