Anorexia nervosa and gut microbiota: A systematic review and quantitative synthesis of pooled microbiological data
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2021-03-01; 106: 110114
DOI: 10.1016/j.pnpbp.2020.110114
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Di Lodovico L(1), Mondot S(2), Doré J(2), Mack I(3), Hanachi M(4), Gorwood P(5).
Author information:
(1)Nutrition Unit, Paul Brousse University Hospital, Assistance
Publique-Hôpitaux de Paris, Villejuif, France; GHU Paris Psychiatrie et
Neurosciences, CMME, Hôpital Sainte-Anne, Paris F-75014, France. Electronic
address: .
(2)Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay,
Jouy-en-Josas, France.
(3)Department of Psychosomatic Medicine and Psychotherapy, University Hospital
Tübingen, Tübingen, Germany.
(4)Nutrition Unit, Paul Brousse University Hospital, Assistance
Publique-Hôpitaux de Paris, Villejuif, France; Micalis Institute, INRA,
AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France; Paris-Saclay
University, Le Kremlin-Bicêtre, France.
(5)GHU Paris Psychiatrie et Neurosciences, CMME, Hôpital Sainte-Anne, Paris
F-75014, France; Université de Paris, Institute of Psychiatry and Neuroscience
of Paris (IPNP), INSERM U1266, Paris F-75014, France.
BACKGROUND: Alterations of gut microbiota may play a role in Anorexia Nervosa
(AN) through perturbations of the gut-brain axis. Some studies found differences
in the gut microbiota of patients with AN compared to healthy controls, but
results are heterogeneous. The aim of this work was to systematically review the
existing studies comparing gut microbial composition in AN and healthy controls,
and to perform a quantitative synthesis of the pooled clinical and
microbiological data, when available.
METHODS: A comprehensive literature search was performed to identify human
studies investigating relationships between AN and gut microbiota. Microbiome
datasets from studies were pooled and analysed focusing on alpha and
beta-diversity and the relative abundance of microbial species in patients’ gut
microbiota compared to healthy controls.
RESULTS: Nine studies were eligible for the systematic review, of which 4 were
included in the quantitative synthesis. Preserved alpha-diversity and decreased
beta-diversity in AN emerged from the qualitative synthesis, while a slight
increase of alpha-diversity (d