Angiopoietin-2 regulates cortical neurogenesis in the developing telencephalon.
Cerebral Cortex. 2010-12-02; 21(7): 1695-1702
DOI: 10.1093/cercor/bhq243
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1. Cereb Cortex. 2011 Jul;21(7):1695-702. doi: 10.1093/cercor/bhq243. Epub 2010 Dec
2.
Angiopoietin-2 regulates cortical neurogenesis in the developing telencephalon.
Marteau L(1), Pacary E, Valable S, Bernaudin M, Guillemot F, Petit E.
Author information:
(1)UMR 6232 CI-NAPS, Université de Caen Basse-Normandie, Université
Paris-Descartes, CNRS, CEA, Centre Cyceron, 14074 Caen Cedex, France.
Vascular-specific growth factor angiopoietin-2 (Ang2) is mainly involved during
vascular network setup. Recently, Ang2 was suggested to play a role in adult
neurogenesis, affecting migration and differentiation of adult neuroblasts in
vitro. However, to date, no data have reported an effect of Ang2 on neurogenesis
during embryonic development. As we detected Ang2 expression in the developing
cerebral cortex at embryonic day E14.5 and E16.5, we used in utero
electroporation to knock down Ang2 expression in neuronal progenitors located in
the cortical ventricular zone (VZ) to examine the role of Ang2 in cortical
embryonic neurogenesis. Using this strategy, we showed that radial migration from
the VZ toward the cortical plate of Ang2-knocked down neurons is altered as well
as their morphology. In parallel, we observed a perturbation of intermediate
progenitor population and the surrounding vasculature. Taken together, our
results show for the first time that, in addition to its role during brain
vasculature setup, Ang2 is also involved in embryonic cortical neurogenesis and
especially in the radial migration of projection neurons.
DOI: 10.1093/cercor/bhq243
PMID: 21127017 [Indexed for MEDLINE]