Anatomical predictors of successful prism adaptation in chronic visual neglect

Marine Lunven, Gilles Rode, Clémence Bourlon, Christophe Duret, Raffaella Migliaccio, Emmanuel Chevrillon, Michel Thiebaut de Schotten, Paolo Bartolomeo
Cortex. 2018-12-01; :
DOI: 10.1016/j.cortex.2018.12.004

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Lunven M(1), Rode G(2), Bourlon C(3), Duret C(4), Migliaccio R(5), Chevrillon E(6), Thiebaut de Schotten M(7), Bartolomeo P(8).

Author information:
(1)Inserm U 1127, CNRS UMR 7225, Sorbonne Université, UPMC Univ Paris 06 UMR S
1127, Institut du Cerveau et de la Moelle épinière, ICM, Hôpital de la
Pitié-Salpêtrière, Paris, France; Service de Médecine Physique et Réadaptation,
Unité de Rééducation Neurologique CRF “Les Trois Soleils” Boissise le Roi,
France; Inserm UMR_S 1028, CNRS UMR 5292, ImpAct, centre des neurosciences de
Lyon, université Lyon-1, 16, avenue Lépine, Bron, France; Brain connectivity and
Behaviour Group, Sorbonne Université, Paris, France; Laboratoire de
Neuropsychologie Interventionnelle, Département d’études cognitives, ENS, PSL
Research University, UPEC, Université Paris-Est, CNRS, Paris, France.
(2)Inserm UMR_S 1028, CNRS UMR 5292, ImpAct, centre des neurosciences de Lyon,
université Lyon-1, 16, avenue Lépine, Bron, France; Service de médecine physique
et réadaptation neurologique, hôpital Henry-Gabrielle, hospices civils de Lyon,
20, route de Vourles, Saint-Genis-Laval, France.
(3)Service de Médecine Physique et Réadaptation, Unité de Rééducation
Neurologique CRF “Les Trois Soleils” Boissise le Roi, France; Hôpitaux de Saint
Maurice, Saint Maurice, France.
(4)Service de Médecine Physique et Réadaptation, Unité de Rééducation
Neurologique CRF “Les Trois Soleils” Boissise le Roi, France.
(5)Inserm U 1127, CNRS UMR 7225, Sorbonne Université, UPMC Univ Paris 06 UMR S
1127, Institut du Cerveau et de la Moelle épinière, ICM, Hôpital de la
Pitié-Salpêtrière, Paris, France.
(6)Clinique du Bourget, Le Bourget, France.
(7)Inserm U 1127, CNRS UMR 7225, Sorbonne Université, UPMC Univ Paris 06 UMR S
1127, Institut du Cerveau et de la Moelle épinière, ICM, Hôpital de la
Pitié-Salpêtrière, Paris, France; Brain connectivity and Behaviour Group,
Sorbonne Université, Paris, France; Groupe d’Imagerie Neurofonctionnelle,
Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA University of
Bordeaux, Bordeaux, France.
(8)Inserm U 1127, CNRS UMR 7225, Sorbonne Université, UPMC Univ Paris 06 UMR S
1127, Institut du Cerveau et de la Moelle épinière, ICM, Hôpital de la
Pitié-Salpêtrière, Paris, France. Electronic address: .

Visual neglect is a frequent and disabling consequence of right hemisphere
damage. Previous work demonstrated a probable role of posterior callosal
dysfunction in the chronic persistence of neglect signs. Prism adaptation is a
non-invasive and convenient technique to rehabilitate chronic visual neglect, but
it is not effective in all patients. Here we aimed to assess the hypothesis that
prism adaptation improves left neglect by facilitating compensation through the
contribution of the left, undamaged hemisphere. We assessed the relationship
between prism adaptation effects, cortical thickness and white matter integrity
in a group of 14 patients with unilateral right-hemisphere strokes and chronic
visual neglect. Results showed that patients who benefitted from prism adaptation
had thicker cortex in temporo-parietal, prefrontal and cingulate areas of the
left, undamaged hemisphere. Additionally, these patients had a higher fractional
anisotropy value in the body and genu of the corpus callosum. Results from normal
controls show that these callosal regions connect temporo-parietal, sensorimotor
and prefrontal areas. Finally, shorter time intervals from the stroke tended to
improve patients’ response to prism adaptation. We concluded that prism
adaptation may improve left visual neglect by promoting the contribution of the
left hemisphere to neglect compensation. These results support current hypotheses
on the role of the healthy hemisphere in the compensation for stroke-induced,
chronic neuropsychological deficits, and suggest that prism adaptation can foster
this role by exploiting sensorimotor/prefrontal circuits, especially when applied
at early stages post-stroke.

Copyright © 2018 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.cortex.2018.12.004
PMID: 30621959

Auteurs Bordeaux Neurocampus