An Embedded Deep Brain Stimulator for Biphasic Chronic Experiments in Freely Moving Rodents
IEEE Trans. Biomed. Circuits Syst.. 2016-02-01; 10(1): 72-84
DOI: 10.1109/TBCAS.2014.2368788
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1. IEEE Trans Biomed Circuits Syst. 2016 Feb;10(1):72-84. doi:
10.1109/TBCAS.2014.2368788. Epub 2014 Dec 23.
An Embedded Deep Brain Stimulator for Biphasic Chronic Experiments in Freely
Moving Rodents.
Kölbl F, N’Kaoua G, Naudet F, Berthier F, Faggiani E, Renaud S, Benazzouz A,
Lewis N.
This paper describes a Deep Brain Stimulation device, portable, for chronic
experiments on rodents in the context of Parkinson’s disease. Our goal is to
equip the animal with a device that mimics the human therapeutic conditions. It
implies to respect a set of properties such as bilateral current-mode and
charge-balanced stimulation, as well as programmability, low power consumption
and re-usability to finally reach a suitable weight for long-term experiments.
After the analysis of the solutions found in the literature, the full design of
the device is explained. First, the stimulation front-end circuit driven by a
processor unit, then the choice of supply sources which is a critical point for
the weight and life-time of our system. Our low cost system has been realized
using commercial discrete components and the overall power consumption was
minimized. We achieved 6 days of maximal current stimulation with the chosen
battery for a weight of 13.8 g . Finally, the device was carried out in vivo on
rats during a 3 weeks experiment as the used implantation technique allows
battery changing. This experiment also permits to emphasize the mechanical
aspects including the packaging and electrodes holding.
DOI: 10.1109/TBCAS.2014.2368788
PMID: 25546861 [Indexed for MEDLINE]