An animal model of a spontaneously reversible obstructive sleep apnea syndrome in the monkey.
Neurobiology of Disease. 2005-11-01; 20(2): 428-431
DOI: 10.1016/j.nbd.2005.03.024
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1. Neurobiol Dis. 2005 Nov;20(2):428-31.
An animal model of a spontaneously reversible obstructive sleep apnea syndrome in
the monkey.
Philip P(1), Gross CE, Taillard J, Bioulac B, Guilleminault C.
Author information:
(1)Clinique du Sommeil, CHU Pellegrin, Bordeaux, France.
The anatomies of the tongue and uvula in monkeys share many similarities with
humans, such that this species has the closest approximation to the human upper
airway than any other species. In this study, we investigated the feasibility of
using small monkeys as experimental animals for an obstructive sleep apnea model.
Monkeys received intradermal injections of liquid collagen in the uvula, tongue,
and lateral pharyngeal walls every 2 weeks. Polysomnography was performed
bi-monthly in order to control the impact of injections on breathing events,
respiratory effort (as measured by esophageal pressure), and sleep. Before
injections, the three animals showed normal breathing during sleep with a mean of
4.8 +/- 2.0 events/h. After injections, a mean of 27.9 +/- 19.7 hypopneas/h was
recorded (P = 0.023). Total sleep time was significantly reduced, with a decrease
of REM sleep and stage II sleep; however, stage I sleep increased. Collagen
injections in monkey’s upper airways can create sleep-disordered breathing and
abnormal sleep, as seen in sleep apneic patients.
DOI: 10.1016/j.nbd.2005.03.024
PMID: 15886006 [Indexed for MEDLINE]