Amyloid and its association with default network integrity in Alzheimer’s disease

Sofie M. Adriaanse, Ernesto J. Sanz-Arigita, Maja A.A. Binnewijzend, Rik Ossenkoppele, Nelleke Tolboom, Daniëlle M.E. van Assema, Alle Meije Wink, Ronald Boellaard, Maqsood Yaqub, Albert D. Windhorst, Wiesje M. van der Flier, Philip Scheltens, Adriaan A. Lammertsma, Serge A.R.B. Rombouts, Frederik Barkhof, Bart N.M. van Berckel
Hum. Brain Mapp. 2012-12-14; 35(3): 779-791
DOI: 10.1002/hbm.22213

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1. Hum Brain Mapp. 2014 Mar;35(3):779-91. doi: 10.1002/hbm.22213. Epub 2012 Dec 14.

Amyloid and its association with default network integrity in Alzheimer’s

Adriaanse SM(1), Sanz-Arigita EJ, Binnewijzend MA, Ossenkoppele R, Tolboom N, van
Assema DM, Wink AM, Boellaard R, Yaqub M, Windhorst AD, van der Flier WM,
Scheltens P, Lammertsma AA, Rombouts SA, Barkhof F, van Berckel BN.

Author information:
(1)Department of Nuclear Medicine and PET Research, Alzheimer Center Amsterdam,
VU University Medical Center, Amsterdam, The Netherlands.

The purpose of this study was to investigate the association between functional
connectivity and β-amyloid depositions in the default mode network (DMN) in
Alzheimer’s disease (AD), patients with mild cognitive impairment (MCI), and
healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18
healthy controls were included in the study. Resting-state functional magnetic
resonance imaging was used to assess functional connectivity in the DMN. In
parallel, amyloid burden was measured in the same subjects using positron
emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid
tracer. Functional connectivity of the DMN and amyloid deposition within the DMN
were not associated across all subjects or within diagnostic groups. Longitudinal
studies are needed to examine if amyloid depositions precede aberrant functional
connectivity in the DMN.

Copyright © 2012 Wiley Periodicals, Inc.

DOI: 10.1002/hbm.22213
PMCID: PMC6869670
PMID: 23238869 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus