AMINO-ACID-ANALYSIS DEMONSTRATES THAT INCREASED PLASMA-FREE TRYPTOPHAN CAUSES THE INCREASE OF BRAIN TRYPTOPHAN DURING EXERCISE IN THE RAT
J Neurochem. 1986-05-01; 46(5): 1647-1650
DOI: 10.1111/j.1471-4159.1986.tb01789.x
Lire sur PubMed
1. J Neurochem. 1986 May;46(5):1647-50.
Amino acid analysis demonstrates that increased plasma free tryptophan causes the
increase of brain tryptophan during exercise in the rat.
Chaouloff F, Kennett GA, Serrurrier B, Merino D, Curzon G.
Rats were trained to run on a horizontal treadmill for 2 h at 20 m/min. This
activity considerably increased plasma free tryptophan (TRP) (+70%) but did not
alter plasma total TRP levels and had little or no effect on plasma
concentrations of the other large neutral amino acids (LNAAs) that compete with
TRP for entry into the brain. Brain TRP levels increased by 80%. The only other
brain LNAA to be affected by exercise was threonine, which rose moderately. The
results indicate that increased plasma free TRP was specifically responsible for
the increase of brain TRP after 2 h of exercise. Brain lysine was also increased
whereas glycine, alanine, and gamma-aminobutyric acid were decreased. The
differences between the present findings and those previously obtained following
2 h immobilization stress are discussed.
DOI: 10.1111/j.1471-4159.1986.tb01789.x
PMID: 3083049 [Indexed for MEDLINE]