Alzheimer’s Disease and Helicobacter pylori Infection: Inflammation from Stomach to Brain?

Guillaume Albaret, Elodie Sifré, Pauline Floch, Sophie Laye, Agnès Aubert, Pierre Dubus, Lamia Azzi-Martin, Alban Giese, Nathalie Salles, Francis Mégraud, Christine Varon, Philippe Lehours, Claire Roubaud-Baudron
JAD. 2020-01-21; 73(2): 801-809
DOI: 10.3233/jad-190496

Lire sur PubMed

Albaret G(1)(2), Sifré E(1), Floch P(1), Laye S(3), Aubert A(3), Dubus P(1)(4), Azzi-Martin L(1), Giese A(1), Salles N(1)(2), Mégraud F(1)(4), Varon C(1), Lehours P(1)(4), Roubaud-Baudron C(1)(2).

Author information:
(1)University of Bordeaux, UMR BaRITOn, INSERM 1053, Bordeaux, France.
(2)CHU Bordeaux, Pôle de Gérontologie Clinique, Bordeaux, France.
(3)University of Bordeaux, NutriNeuro, INRA 1286, Bordeaux, France.
(4)CHU Bordeaux, Service de biologie des tumeurs – tumorothèque, Bordeaux, France.

Despite extensive research, the origin of Alzheimer’s disease (AD) remains unknown. The role of infectious pathogens has recently emerged. Epidemiological
studies have shown that Helicobacter pylori infection increases the risk of developing AD. We hypothesized that H. pylori-induced gastritis may be associated with a systemic inflammation and finally neuroinflammation. C57BL/6 mice were infected with H. pylori (n = 15) or Helicobacter felis (n = 13) or left uninfected (n = 9) during 18 months. Gastritis, amyloid deposition, astroglial and microglial cell area, and systemic and brain cytokines were assessed. The infection (H. felis> H. pylori) induced a severe gastritis and an increased neuroinflammation but without brain amyloid deposition or systemic inflammation.

DOI: 10.3233/JAD-190496
PMID: 31868664

Auteurs Bordeaux Neurocampus