Altered sleep quality is associated with Crohn’s disease activity: an actimetry study.
Sleep Breath. 2019-09-12; :
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Bazin T(1)(2), Micoulaud Franchi JA(3)(4), Terras N(2), Taillard J(3), Laharie D(2), Zerbib F(2), Philip P(5)(6)(7).
(1)University of Bordeaux, INRA, EA 3671, CHU Bordeaux, F-33000, Bordeaux, France.
(2)Gastroenterology and Hepatology Department, Hôpital Haut Lévêque, Centre Hospitalier Universitaire de Bordeaux and Université de Bordeaux, F-33000, Bordeaux, France.
(3)University Bordeaux, CNRS, SANPSY, USR 3413, F-33000, Bordeaux, France.
(4)Bordeaux Hospital University Center, Clinique du sommeil, F-33000, Bordeaux, France.
(5)University Bordeaux, CNRS, SANPSY, USR 3413, F-33000, Bordeaux, France. .
(6)Bordeaux Hospital University Center, Clinique du sommeil, F-33000, Bordeaux, France. .
(7)GENPPHASS, Hôpital Pellegrin, Tripode 13ème Etage, Place Amélie Raba Léon, F-33076, Bordeaux CEDEX, France. .
BACKGROUND: Sleep is involved in the regulation of inflammation, healing, and digestion. The pathophysiology of Crohn’s disease (CD) is unclear, and the role of sleep disturbances has recently been suggested.
OBJECTIVE: The present study investigated a putative association between sleep disturbances and CD activity.
METHODS: We conducted a prospective observational monocenter translational study, recruiting major CD patients from 2013 to 2015. Disease activity was assessed by the Harvey-Bradshaw index and the CD activity index. Objective sleep quantity and quality were measured by wrist actigraphy over a period of 7 days. The primary objective was to look for an association between wrist actigraphy parameters and CD activity.
RESULTS: Thirty-four CD patients, including 14 with active disease and 20 in remission, were included. Sleep efficiency measured by wrist actigraphy was lower in patients with active CD compared to patients in remission. Wake after sleep onset time best predicted CD activity with an AUROC of 0.83. Patients with active CD were more frequently characterized as « poor sleepers » and frequently suffered from excessive daytime sleepiness.
CONCLUSION: Sleep efficiency is lower in patients with active CD than in those in remission. Further studies aimed at better characterizing CD patients’ sleep are warranted.