Alpha-synuclein and transgenic mouse models

1. Neurobiol Dis. 2004 Nov;17(2):123-30. doi: 10.1016/j.nbd.2004.07.001.

Alpha-synuclein and transgenic mouse models.

Fernagut PO(1), Chesselet MF.

Author information:
(1)Departments of Neurology and Neurobiology, The David Geffen School of
Medicine at UCLA, Los Angeles, CA 90095-1769, USA.

Identified as the cause of some familial forms of Parkinson disease (PD) and as
one of the major component of Lewy bodies, alpha-synuclein (alpha-syn) became
the molecular hallmark of several neurodegenerative conditions now designated as
synucleinopathies. Transgenic models have been generated to elucidate its
physiological and pathologic roles. Although none of the lines created display
dopaminergic neuronal death in the substantia nigra, the models recapitulate
some features of synucleinopathies and are useful to study the potential
pathogenic role of alpha-synuclein and its molecular partners. This review
describes the different alpha-synuclein transgenic models, their clinical
relevance to synucleinopathies, and their further utilization to understand the
disease process.

DOI: 10.1016/j.nbd.2004.07.001
PMID: 15474350 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus