Alleviation of experimental hemiparkinsonism by high-frequency stimulation of the subthalamic nucleus in primates: A comparison with L-Dopa treatment
Mov. Disord.. 1996-11-01; 11(6): 627-632
DOI: 10.1002/mds.870110606
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1. Mov Disord. 1996 Nov;11(6):627-32. doi: 10.1002/mds.870110606.
Alleviation of experimental hemiparkinsonism by high-frequency stimulation of
the subthalamic nucleus in primates: a comparison with L-Dopa treatment.
Benazzouz A(1), Boraud T, Féger J, Burbaud P, Bioulac B, Gross C.
Author information:
(1)Laboratoire de Neurophysiologie, CNRS URA 1200, Université de Bordeaux II,
France.
Experimental studies in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP)-treated monkeys have shown that akinesia and rigidity are linked to a
hyperactivity of glutamatergic subthalamic nucleus neurons and that the lesion
of this nucleus can ameliorate parkinsonian motor signs. In our study,
high-frequency stimulation applied at the subthalamic level was performed on two
Macaca mulatta monkeys rendered hemiparkinsonian by unilateral infusion of MPTP.
Its effects on rigidity and bradykinesia have been quantified. The results
exhibit an important alleviation of both symptoms during the application of
subthalamic stimulation comparable to that obtained during L-Dopa treatment, but
without the appearance of abnormal movements such hemiballism or dyskinesia. Our
data show that subthalamic stimulation has a beneficial effect on experimental
parkinsonian rigidity and bradykinesia and suggests a new therapy approach for
the treatment of Parkinson’s disease by using subthalamic high-frequency
stimulation instead of L-Dopa treatment.
DOI: 10.1002/mds.870110606
PMID: 8914087 [Indexed for MEDLINE]