Age-Related Modifications of Diffusion Tensor Imaging Parameters and White Matter Hyperintensities as Inter-Dependent Processes.
Front. Aging Neurosci.. 2016-01-19; 7:
DOI: 10.3389/fnagi.2015.00255
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1. Front Aging Neurosci. 2016 Jan 19;7:255. doi: 10.3389/fnagi.2015.00255.
eCollection 2015.
Age-Related Modifications of Diffusion Tensor Imaging Parameters and White Matter
Hyperintensities as Inter-Dependent Processes.
Pelletier A(1), Periot O(2), Dilharreguy B(3), Hiba B(4), Bordessoules M(2),
Chanraud S(5), Pérès K(6), Amieva H(6), Dartigues JF(6), Allard M(7), Catheline
G(5).
Author information:
(1)INCIA, UMR 5287, Université de BordeauxTalence, France; Centre National de la
Recherche Scientifique, INCIA, UMR 5287Talence, France; ISPED, Centre ISPED,
Institut National de la Santé et de la Recherche Médicale U 1219, Université de
BordeauxBordeaux, France.
(2)INCIA, UMR 5287, Université de BordeauxTalence, France; Centre National de la
Recherche Scientifique, INCIA, UMR 5287Talence, France; CHU de BordeauxBordeaux,
France.
(3)INCIA, UMR 5287, Université de BordeauxTalence, France; Centre National de la
Recherche Scientifique, INCIA, UMR 5287Talence, France.
(4)RMSB, UMR 5536 Bordeaux, France.
(5)INCIA, UMR 5287, Université de BordeauxTalence, France; Centre National de la
Recherche Scientifique, INCIA, UMR 5287Talence, France; EPHEBordeaux, France.
(6)ISPED, Centre ISPED, Institut National de la Santé et de la Recherche Médicale
U 1219, Université de Bordeaux Bordeaux, France.
(7)INCIA, UMR 5287, Université de BordeauxTalence, France; Centre National de la
Recherche Scientifique, INCIA, UMR 5287Talence, France; CHU de BordeauxBordeaux,
France; EPHEBordeaux, France.
Microstructural changes of White Matter (WM) associated with aging have been
widely described through Diffusion Tensor Imaging (DTI) parameters. In parallel,
White Matter Hyperintensities (WMH) as observed on a T2-weighted MRI are
extremely common in older individuals. However, few studies have investigated
both phenomena conjointly. The present study investigates aging effects on DTI
parameters in absence and in presence of WMH. Diffusion maps were constructed
based on 21 directions DTI scans of young adults (n = 19, mean age = 33 SD = 7.4)
and two age-matched groups of older adults, one presenting low-level-WMH (n = 20,
mean age = 78, SD = 3.2) and one presenting high-level-WMH (n = 20, mean age =
79, SD = 5.4). Older subjects with low-level-WMH presented modifications of DTI
parameters in comparison to younger subjects, fitting with the DTI pattern
classically described in aging, i.e., Fractional Anisotropy (FA) decrease/Radial
Diffusivity (RD) increase. Furthermore, older subjects with high-level-WMH showed
higher DTI modifications in Normal Appearing White Matter (NAWM) in comparison to
those with low-level-WMH. Finally, in older subjects with high-level-WMH, FA, and
RD values of NAWM were associated with to WMH burden. Therefore, our findings
suggest that DTI modifications and the presence of WMH would be two
inter-dependent processes but occurring within different temporal windows. DTI
changes would reflect the early phase of white matter changes and WMH would
appear as a consequence of those changes.
DOI: 10.3389/fnagi.2015.00255
PMCID: PMC4718031
PMID: 26834625