Advanced paternal age is associated with earlier schizophrenia onset in offspring. Results from the national multicentric FACE-SZ cohort.
Psychiatry Research. 2017-08-01; 254: 218-223
DOI: 10.1016/j.psychres.2017.04.002
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1. Psychiatry Res. 2017 Aug;254:218-223. doi: 10.1016/j.psychres.2017.04.002.
Epub 2017 Apr 12.
Advanced paternal age is associated with earlier schizophrenia onset in
offspring. Results from the national multicentric FACE-SZ cohort.
Fond G(1), Godin O(2), Boyer L(3), Llorca PM(4), Andrianarisoa M(5), Brunel
L(5), Aouizerate B(6), Berna F(7), Capdevielle D(8), D’Amato T(9), Denizot H(4),
Dubertret C(10), Dubreucq J(11), Faget C(12), Gabayet F(11), Mallet J(10),
Misdrahi D(13), Passerieux C(14), Rey R(9), Richieri R(12), Schandrin A(8),
Urbach M(14), Vidailhet P(15), Leboyer M(5), Bulzacka E(5), Schürhoff F(5);
FACE-SZ group.
Author information:
(1)Fondation FondaMental, Créteil, France; INSERM U955, équipe de psychiatrie
translationnelle, Créteil, France, Université Paris-Est Créteil, DHU Pe-PSY,
Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil, France;
Bordeaux Sleep Clinique, Pellegrin University Hospital, Bordeaux University, USR
CNRS 3413 SANPSY, Research Unit, 33000 Bordeaux, France; Clinique Jeanne d’Arc,
Hôpital Privé Parisien, F-94160 Saint-Mandé, France. Electronic address:
.
(2)Fondation FondaMental, Créteil, France; UPMC University Paris 06, UMRS 943,
F-75013 Paris, France; INSERM, UMRS 943, F-75013 Paris, France.
(3)Fondation FondaMental, Créteil, France; Pôle psychiatrie universitaire, CHU
Sainte-Marguerite, F-13274 Marseille cedex 09, France.
(4)Fondation FondaMental, Créteil, France; CMP B, CHU, EA 7280 Faculté de
Médecine, Université d’Auvergne, BP 69 63003 Clermont-Ferrand Cedex 1, France.
(5)Fondation FondaMental, Créteil, France; INSERM U955, équipe de psychiatrie
translationnelle, Créteil, France, Université Paris-Est Créteil, DHU Pe-PSY,
Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil, France.
(6)Fondation FondaMental, Créteil, France; Centre Hospitalier Charles Perrens,
F-33076 Bordeaux, France; Université de Bordeaux; Inserm, Neurocentre Magendie,
Physiopathologie de la Plasticité Neuronale, U862, F-33000 Bordeaux, France.
(7)Fondation FondaMental, Créteil, France; Hôpitaux Universitaires de
Strasbourg, Université de Strasbourg, INSERM U1114, Fédération de Médecine
Translationnelle de Strasbourg, Strasbourg, France.
(8)Fondation FondaMental, Créteil, France; Service Universitaire de Psychiatrie
Adulte, Hôpital la Colombière, CHRU Montpellier, Université Montpellier 1,
Inserm 1061, Montpellier, France.
(9)Fondation FondaMental, Créteil, France; INSERM U1028, CNRS UMR5292, Centre de
Recherche en Neurosciences de Lyon, Université Claude Bernard Lyon 1, Equipe
PSYR2, Centre Hospitalier Le Vinatier, Pole Est, 95 bd Pinel, BP 30039, 69678
Bron Cedex, France.
(10)Fondation FondaMental, Créteil, France; AP-HP, Department of Psychiatry,
Louis Mourier Hospital, Colombes, Inserm U894, Université Paris Diderot,
Sorbonne Paris Cité, Faculté de médecine, France.
(11)Fondation FondaMental, Créteil, France; Centre Référent de Réhabilitation
Psychosociale, CH Alpes Isère, Grenoble, France.
(12)Fondation FondaMental, Créteil, France; Assistance Publique des Hôpitaux de
Marseille (AP-HM), pôle universitaire de psychiatrie, Marseille, France.
(13)Fondation FondaMental, Créteil, France; Centre Hospitalier Charles Perrens,
F-33076 Bordeaux, France; Université de Bordeaux; CNRS UMR 5287-INCIA.
(14)Fondation FondaMental, Créteil, France; Service de psychiatrie d’adulte,
Centre Hospitalier de Versailles, UFR des Sciences de la Santé Simone Veil,
Université Versailles Saint-Quentin en Yvelines, Versailles, France.
(15)Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, INSERM
U1114, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg,
France.
The association between advanced paternal age (APA) and increased risk of
schizophrenia (SZ) is well established. The objectives of the present study were
to further determine if SZ participants with APA (APA+), versus those without
(APA-), had: (i) different illness characteristics; (ii) different responses to
antipsychotic medication; and (iii) different cognitive characteristics.
Participants were a non-selected representative multicentric sample of
stabilized community-dwelling people diagnosed with SZ included in the FACE-SZ
cohort. 389 participants (73% males, mean aged 32.7 years, mean illness duration
10.8 years) formed the study sample, with each comprehensively evaluated,
clinically and neuropsychologically, over 2 days. 118 participants (30.3%) were
defined as APA+ according to their father’s age at birth (≥35 years). APA+ was
associated with a wide range of cognitive dysfunctions in univariate analyses.
In multivariate analyses, the only significant difference was the age at onset,
with a mean 1.6 year earlier in APA+, compared to APA- (20.7 vs. 22.3 years;
p=0.02). This difference is independent of sociodemographic characteristics and
I.Q. No association with clinical symptomatology and treatment response was
found. The present study supports the neomutation hypothesis and confirms APA as
a relevant clinical variable to discriminate potential schizophrenia subtypes.
Potential underlying pathophysiological mechanisms are discussed.
Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.
DOI: 10.1016/j.psychres.2017.04.002
PMID: 28476014 [Indexed for MEDLINE]