Advanced multiparametric magnetic resonance imaging of multinodular and vacuolating neuronal tumor.
Lecler A(1), Broquet V(2), Bailleux J(1), Carsin B(3), Adle-Biassette H(4), Baloglu S(5), Forestier G(6), Bonneville F(7), Calvier E(8), Chauvet D(9), Comby PO(10), Cottier JP(11)(12), Cotton F(13), Deschamps R(14), Diard-Detoeuf C(15), Ducray F(16), Drissi C(17), Elmaleh M(18), Farras J(19), Aguilar Garcia J(8), Gerardin E(20), Grand S(21), Jianu DC(22), Kremer S(5), Loiseau H(23), Magne N(20), Mejdoubi M(24), Moulignier A(14), Ollivier M(25), Nagi S(17)(26), Rodallec M(27), Shor N(28), Tourdias T(29), Vandendries C(1)(30), Anxionnat R(31), Duron L(1), Savatovsky J(1)(32).
Author information:
(1)Department of Neuroradiology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
(2)Department of Neuroradiology, CHU Lille, Lille, France.
(3)Department of Radiology, CHRU de Rennes, Rennes, France.
(4)Department of Pathology, Lariboisière Hospital, Paris Diderot,
Paris-Cité-Sorbonne University, Paris, France.
(5)Department of Radiology, University Hospital of Strasbourg, Strasbourg, France.
(6)Department of Neuroradiology, CHU Limoges, Limoges, France.
(7)Department of Neuroradiology, Hôpital Pierre-Paul-Riquet, CHU Purpan, Toulouse, France.
(8)Neurology Department, Hôpital René et Guillaume-Laënnec, CHU de Nantes, Saint-Herblain, France.
(9)Department of Neurosurgery, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
(10)Department of Vascular and Interventional Radiology, Image-Guided Therapy Center, François-Mitterrand University Hospital, Dijon, France.
(11)Department of Radiology, CHRU de Tours, Tours, France.
(12)Brain and Imaging laboratory, UMR U930, INSERM, François-Rabelais University, Tours, France.
(13)Service de Radiologie, Centre Hospitalier Lyon-Sud, 69495 Pierre-Bénite, Hospices Civils de Lyon, University Claude Bernard Lyon 1, Lyon, France.
(14)Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
(15)Department of Neurology, CH Sainte-Perrine, Paris, France.
(16)Department of Neuro-oncology, Lyon French Reference Center of Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Lyon, France.
(17)Faculté de Médecine de Tunis, Institut National de Neurologie, Service de Neuroradiologie, Université de Tunis El Manar, Tunis, Tunisia.
(18)Pediatric Radiology Department, Robert Debré Hospital, Paris, France.
(19)Jordi Radiologia C/ de la Roda, Andorra la Vella, Andorra.
(20)Department of Neuroradiology and MRI, Rouen University Hospital, Rouen, France.
(21)Neuroradiologie diagnostique et interventionnelle et IRM Nord ‘Centre Hospitalier et Universitaire de Alpes Grenoble’, Grenoble, France.
(22)Department of Neurology, Victor Babes University of Medecine and Pharmacy, Timisoara, Romania.
(23)Service de Neurochirurgie, CHU de Bordeaux, Université de Bordeaux, Bordeaux, France.
(24)Department of Neuroradiology, University Hospital of Martinique, Fort-de-France, France.
(25)Service de Radiologie, Groupe Hospitalier Pellegrin, Bordeaux, France.
(26)Clinique les Berges du Lac, rue du Lac de Constance, Tunis, Tunisia.
(27)Centre d’Imagerie Centre Cardiologique du Nord, CCN, Saint-Denis, France.
(28)Department of Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.
(29)Service de Neuroimagerie Diagnostique et Thérapeutique, CHU de Bordeaux et INSERM U1215, Université de Bordeaux, Bordeaux, France.
(30)Centre d’Imagerie Médicale Paris 15ème, RMX, Paris, France.
(31)Service de Radiologie, CHU de Nancy, Nancy, France.
(32)Centre d’Imagerie Paris 13, Paris, France.
BACKGROUND AND PURPOSE: Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a rare brain lesion with suggestive imaging features. The aim of our study was to report the largest series of MVNTs so far and to evaluate the utility of advanced multiparametric magnetic resonance (MR) techniques.
METHODS: This multicenter retrospective study was approved by our institutional research ethics board. From July 2014 to May 2019, two radiologists read in consensus the MR examinations of patients presenting with a lesion suggestive of an MVNT. They analyzed the lesions’ MR characteristics on structural images and advanced multiparametric MR imaging.
RESULTS: A total of 64 patients (29 women and 35 men, mean age 44.2 ± 15.1 years) from 25 centers were included. Lesions were all hyperintense on fluid-attenuated inversion recovery and T2-weighted imaging without post-contrast enhancement. The median relative apparent diffusion coefficient on diffusion-weighted imaging was 1.13 [interquartile range (IQR), 0.2. Perfusion-weighted imaging showed no increase in perfusion, with a relative cerebral blood volume of 1.02 (IQR, 0.05) and a relative cerebral blood flow of 1.01 (IQR, 0.08). MR spectroscopy showed no abnormal peaks. Median follow-up was 2 (IQR, 1.2) years, without any changes in
size.
CONCLUSIONS: A comprehensive characterization protocol including advanced multiparametric magnetic resonance imaging sequences showed no imaging patterns suggestive of malignancy in MVNTs. It might be useful to better characterize MVNTs.
© 2020 European Academy of Neurology.