Adipose inflammation in obesity: relationship with circulating levels of inflammatory markers and association with surgery-induced weight loss.
The Journal of Clinical Endocrinology & Metabolism. 2014-01-01; 99(1): E53-E61
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1. J Clin Endocrinol Metab. 2014 Jan;99(1):E53-61. doi: 10.1210/jc.2013-2673. Epub
2013 Dec 20.
Adipose inflammation in obesity: relationship with circulating levels of
inflammatory markers and association with surgery-induced weight loss.
Lasselin J(1), Magne E, Beau C, Ledaguenel P, Dexpert S, Aubert A, Layé S,
(1)Department of Nutrition and Integrative Neurobiology (NutriNeuro), Unité Mixte
de Recherche 1286, Institut National de la Recherche Agronomique (J.L., S.D.,
A.A., S.L., L.C.), and University of Bordeaux (J.L., S.D., A.A., S.L., L.C.),
F-33076 Bordeaux, France; Service de Chirurgie Digestive et Pariétale, Clinique
Tivoli (E.M., C.B., P.L.), F-33000 Bordeaux, France; and Clinique Jean Villar
(E.M., C.B., P.L.), F-33520,Bruges, France.
CONTEXT: The inflammatory state of the adipose tissue is believed to contribute
to systemic low-grade inflammation in obesity.
OBJECTIVE: This study assessed the relationship between adipose and circulating
inflammatory markers as well as the influence of adipose inflammation on
bariatric surgery-induced weight reduction.
DESIGN: This was a cross-sectional and longitudinal study (up to 14 mo).
SETTING: The study was conducted in the digestive/bariatric surgery department of
the Tivoli and Jean Villar clinics, Bordeaux, France.
PATIENTS: Thirty-seven obese patients [body mass index (BMI)>35-40 kg/m2)]
seeking bariatric surgery were included. Twenty-eight of them were successively
followed up at 1-3 months after surgery and 25 between 6 and 14 months after
MAIN OUTCOME MEASURES: Fasting serum samples were collected before surgery to
assess concentrations of inflammatory markers. Samples of visceral adipose tissue
were extracted during surgery and gene expression of cytokines and immune cell
markers were evaluated using quantitative RT-PCR. Pre- and postsurgery weight and
BMI were collected.
RESULTS: Gene expression of several cytokines were strongly intercorrelated in
the visceral adipose tissue. Adipose expression of macrophage and T cell markers
were related to adipose expression of TNF-α and IL-1 receptor antagonist (P