Acute stress facilitates hippocampal CA1 metabotropic glutamate receptor-dependent long-term depression
Journal of Neuroscience. 2007-07-04; 27(27): 7130-7135
DOI: 10.1523/jneurosci.1150-07.2007
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1. J Neurosci. 2007 Jul 4;27(27):7130-5.
Acute stress facilitates hippocampal CA1 metabotropic glutamate
receptor-dependent long-term depression.
Chaouloff F(1), Hémar A, Manzoni O.
Author information:
(1)Centre National de la Recherche Scientifique Unité Mixte de Recherche 5091
Physiologie Cellulaire de la Synapse, Institut François Magendie, 33077 Bordeaux,
France.
Acute stress affects NMDA receptor (NMDAR)-dependent synaptic plasticity in the
CA1 region of the hippocampus, with long-term potentiation and long-term
depression (LTD) being, respectively, diminished and facilitated by acute
exposure to stress. Here, we examined whether this facilitatory effect of stress
on NMDAR-dependent LTD extends to metabotropic glutamate receptor
(mGluR)-dependent LTD at Schaffer collateral-CA1 synapses. Application of a low
dose (50 microM) of the selective group 1 mGluR agonist
(RS)-3,5-dihydroxyphenylglycine (DHPG) promoted LTD in slices from stressed, but
not from control, rats. Pretreatment of stressed rats with the glucocorticoid
receptor (GR) antagonist RU38486 prevented the facilitation of DHPG-induced LTD
(DHPG-LTD), indicating the involvement of corticosterone secretion and, in turn,
stimulation of GRs. Finally, pretreatment of slices with an mGluR1, but not an
mGluR5, antagonist blunted the sensitizing effect of stress on DHPG-LTD. These
results indicate that acute stress, through corticosterone stimulation of GRs,
facilitates the expression of mGluR1-dependent DHPG-LTD in the hippocampal CA1
region.
DOI: 10.1523/JNEUROSCI.1150-07.2007
PMCID: PMC6794579
PMID: 17611266 [Indexed for MEDLINE]