Activity-dependent synaptic plasticity of NMDA receptors.
The Journal of Physiology. 2010-01-01; 588(1): 93-99
DOI: 10.1113/jphysiol.2009.179382
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1. J Physiol. 2010 Jan 1;588(Pt 1):93-9. doi: 10.1113/jphysiol.2009.179382. Epub
2009 Oct 12.
Activity-dependent synaptic plasticity of NMDA receptors.
Rebola N(1), Srikumar BN, Mulle C.
Author information:
(1)Laboratoire Physiologie Cellulaire de la Synapse, CNRS, Bordeaux Neuroscience
Institute, University of Bordeaux, 33077 Bordeaux Cedex, France.
Activity-dependent, bidirectional control of synaptic efficacy is thought to
contribute to many forms of experience-dependent plasticity, including learning
and memory. Although most excitatory synapses contain both AMPA and
N-methyl-d-aspartate receptors (AMPARs and NMDARs), most studies have focused on
the plasticity of synaptic AMPARs, and on the pivotal role of NMDA receptors for
its induction. Here we review evidence that synaptic NMDARs themselves are
subject to long-term activity-dependent changes by mechanisms that may differ
from that of synaptic AMPARs. The bidirectional modulation of NMDAR-mediated
synaptic responses is likely to have important functional implications for
NMDAR-dependent forms of synaptic plasticity.
DOI: 10.1113/jphysiol.2009.179382
PMCID: PMC2821550
PMID: 19822542 [Indexed for MEDLINE]