Abnormal wiring of CCK+ basket cells disrupts spatial information coding

Isabel del Pino, Jorge R Brotons-Mas, André Marques-Smith, Aline Marighetto, Andreas Frick, Oscar Marín, Beatriz Rico
Nat Neurosci. 2017-04-10; 20(6): 784-792
DOI: 10.1038/nn.4544

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1. Nat Neurosci. 2017 Jun;20(6):784-792. doi: 10.1038/nn.4544. Epub 2017 Apr 10.

Abnormal wiring of CCK+ basket cells disrupts spatial information coding.

Del Pino I(#)(1)(2), Brotons-Mas JR(#)(2), Marques-Smith A(1)(3), Marighetto
A(4), Frick A(4), Marín O(1)(2)(3), Rico B(1)(2)(3).

Author information:
(1)Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and
Neuroscience, King’s College London, London SE1 1UL, United Kingdom.
(2)Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas &
Universidad Miguel Hernández, Sant Joan d’Alacant 03550, Spain.
(3)MRC Centre for Neurodevelopmental Disorders, King’s College London, London SE1
1UL, United Kingdom.
(4)Neurocentre Magendie INSERM U1215, 33077 Bordeaux, France.
(#)Contributed equally

The function of cortical GABAergic interneurons is largely determined by their
integration into specific neural circuits, but the mechanisms controlling the
wiring of these cells remain largely unknown. This is particularly true for a
major population of basket cells that express the neuropeptide cholecystokinin
(CCK). Here we found that the tyrosine kinase receptor ErbB4 was required for the
normal integration into cortical circuits of basket cells expressing CCK and
vesicular glutamate transporter 3 (VGlut3). The number of inhibitory synapses
made by CCK+VGlut3+ basket cells and the inhibitory drive they exerted on
pyramidal cells were reduced in conditional mice lacking ErbB4. Developmental
disruption of the connectivity of these cells diminished the power of theta
oscillations during exploratory behavior, disrupted spatial coding by place
cells, and caused selective alterations in spatial learning and memory in adult
mice. These results suggest that normal integration of CCK+ basket cells in
cortical networks is key to support spatial coding in the hippocampus.

DOI: 10.1038/nn.4544
PMCID: PMC5446788
PMID: 28394324 [Indexed for MEDLINE]

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