A quantitative trait locus on chromosome 1 modulates intermale aggression in mice
Genes, Brain and Behavior. 2018-04-27; : e12469
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A quantitative trait locus on chromosome 1 modulates intermale aggression in
Delprato A(1)(2)(3), Bonheur B(1)(2), Algéo MP(1)(2), Murillo A(3), Dhawan E(3),
Lu L(4), Williams RW(4), Crusio WE(1)(2).
(1)Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, UMR 5287,
University of Bordeaux, Pessac Cedex, France.
(2)CNRS, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, UMR
5287, Pessac Cedex, France.
(3)BioScience Project, Wakefield, Massachusetts.
(4)Department of Genetics, Genomics and Informatics, University of Tennessee
Health Sciences Center, Memphis, Tennessee.
Aggression between male conspecifics is a complex social behavior that is likely
modulated by multiple gene variants. In this study, the BXD recombinant inbred
mouse strains (RIS) were used to map quantitative trait loci (QTLs) underlying
behaviors associated with intermale aggression. Four hundred and fifty-seven
males from 55 strains (including the parentals) were observed at an age of
13 ± 1 week in a resident-intruder test following 10 days of isolation. Attack
latency was measured directly within a 10-minute time period and the test was
repeated 24 hours later. The variables we analyzed were the proportion of
attacking males in a given strain as well as the attack latency (on days 1 and 2,
and both days combined). On day 1, 29% of males attacked, and this increased to
37% on day 2. Large strain differences were obtained for all measures of
aggression, indicating substantial heritability (intraclass correlations
0.10-0.18). We identified a significant QTL on chromosome (Chr) 1 and suggestive
QTLs on mouse Chrs 1 and 12 for both attack and latency variables. The
significant Chr 1 locus maps to a gene-sparse region between 82 and 88.5 Mb with
the C57BL/6J allele increasing aggression and explaining about 18% of the
variance. The most likely candidate gene modulating this trait is Htr2b which
encodes the serotonin 2B receptor and has been implicated in aggressive and
impulsive behavior in mice, humans and other species.
© 2018 John Wiley & Sons Ltd and International Behavioural and Neural Genetics