A note on the effect of within-strain sample sizes on QTL mapping in recombinant inbred strain studies

1. Genes Brain Behav. 2004 Aug;3(4):249-51.

A note on the effect of within-strain sample sizes on QTL mapping in recombinant
inbred strain studies.

Crusio WE(1).

Author information:
(1)Brudnick Neuropsychiatric Research Institute, University of Massachusetts
Medical School, Department of Psychiatry, Worcester, MA 01604, USA.

This note explores the effect of within-strain sample sizes on the correlations
between a phenotype and a molecular-genetic marker in a battery of inbred
strains. It is shown that the maximum correlation possible between a molecular
marker and a behavioral or neuronal phenotype equals the additive-genetic
correlation. How close the strain correlation will approach the additive-genetic
correlation depends only on heritability and within-strain sample sizes. The
equations derived can be used to optimize designs of studies attempting to
localize Quantitative Trait Loci utilizing Recombinant Inbred Strains, provided
information about the heritability of the character under study is available.

DOI: 10.1111/j.1601-183X.2004.00079.x
PMID: 15248870 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus