A network analysis of catatonia symptoms across diagnoses
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2024-08-01; 134: 111082
DOI: 10.1016/J.PNPBP.2024.111082
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1. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Aug 30;134:111082. doi:
10.1016/j.pnpbp.2024.111082. Epub 2024 Jul 11.
A network analysis of catatonia symptoms across diagnoses.
Gauld C(1), Expert P(2), Fovet T(3), Amad A(4).
Author information:
(1)Department of Child and Adolescent Psychopathology, CHU de Lyon, F-69000
Lyon, France; Institut des Sciences Cognitives Marc Jeannerod, UMR 5229 CNRS &
Université Claude Bernard Lyon 1, F-69000 Lyon, France.
(2)Global Business School for Health, University College London, London WC1E
6BT, United Kingdom.
(3)Univ. Lille, Inserm, CHU Lille, U1172 – LilNCog – Lille Neuroscience &
Cognition, F-59000 Lille, France.
(4)Univ. Lille, Inserm, CHU Lille, U1172 – LilNCog – Lille Neuroscience &
Cognition, F-59000 Lille, France; Department of neuroimaging, Institute of
Psychiatry, Psychology and Neuroscience, King’s College London, London, UK.
Electronic address: .
BACKGROUND: Catatonia, as a transdiagnostic construct, manifests across various
psychiatric and non-psychiatric conditions. Understanding how symptom variations
impact the catatonia construct and differ across primary diagnoses
(schizophrenia, bipolar disorder, unipolar depression, and
neurological/metabolic/immunological condition) is essential to refine
diagnostic and therapeutic approaches. This study aims to compare the symptom
networks and centrality measures of these diagnoses.
METHODS: We conducted a network analysis using Bush-Francis Catatonia Rating
Scale (BFCRS) data from 118 patients, examining centrality measures and network
comparisons across the four primary diagnostic groups.
RESULTS: In the general catatonia network, the three most central symptoms
identified were Excitement (1.462), Perseveration (1.456), and Impulsivity
(1.332). While the overall structure of the catatonia networks did not show
significant differences between diagnoses in terms of symptom connections and
centrality, variations in centrality measures were observed among the different
networks.
CONCLUSIONS: The study reinforces the notion of catatonia as an independent
syndrome relatively to psychiatric or non-psychiatric diagnoses. However, the
variation in centrality of symptoms across different primary diagnoses provides
critical insights that could aid clinicians in tailoring diagnostic and
therapeutic strategies. Future research should further explore these
relationships and develop more refined approaches to managing catatonia.
Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.pnpbp.2024.111082
PMID: 39002926 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of competing interest The Authors
have declared that there are no conflicts of interest in relation to the subject
of this study.